Cblb−/− BMDCs show increased allogeneic T cell proliferation but are not more effective in the induction of antigen-specific T cell responses and cross-presentation.Stephanie, WallnerChristina, LutzNicoladoniChristoph, H. Tri...
Fig. 2: miR-27b suppresses cell proliferation, colony formation, and promotes chemosensitivity and PTX-induced apoptosis. Full size image Full size image CBLB and GRB2, as candicate target genes of miR-27b, are inversely correlated with chemosensitivity and miR-27b ...
Finally, cytotoxicity assays were performed using the CellTiter 96® AQueous One Solution Cell Proliferation Kit (Promega) in 96-well plates following the manufacturer's instructions. MMAB1 iPSCs were differentiated into HCLs in 96-well plates, and after 20 days the latter were treated with PCs...
proliferation and anergy induction by Cblb UNIVERSITY OF MINNESOTA Daniel Lee Mueller ZhangRuanThough the role of Cbl-b in CD4+ T cell activation, proliferation, and clonal anergy induction has previously been explored, the precise function of Cbl-b in CD4+ T cells is still ambiguous. We ...
Though the role of Cbl-b in CD4+ T cell activation, proliferation, and clonal anergy induction has previously been explored, the precise function of Cbl-b in CD4+ T cells is still ambiguous. We utilized Rag2-/- 5C.C7 TCR-transgenic Cbl-b-/- mice as a model to study in depth the ...
The MS risk-related single nucleotide polymorphism of CBLB rs12487066 is associated with diminished CBL-B expression levels and alters the effects of type I IFNs on human CD4+ T cell proliferation. Mechanistically, the CBLB rs12487066 risk allele mediates increased binding of the transcription ...