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Runx proteins are developmentally important metazoan transcription factors that form a heterodimeric complex with the non-homologous protein Core Binding Factor β (CBFβ). CBFβ allosterically enhances Runx DNA binding but does not bind DNA itself. We report the initial characterization of SpCBFβ, ...
Full size image Although previous studies claimed that iNKT cells are either DN or CD4SP 17, a small DP iNKTp cluster (C14) was indeed uncovered in ST0 (Fig. 3c–e and Supplementary Fig. S4a–d). To rule out the possibility that C14 DP iNKTp might be the contaminated un-signaled DP...
Studying DNA methylation changes in the context of structural rearrangements and point mutations as well as gene expression changes enables the identification of genes that are important for disease onset and progression in different subtypes of acute myeloid leukemia (AML) patients. The aim of this ...
Xu et al. 360 HBV infection assay The supernatants of HepG2.2.15 cells, which were derived from the human hepatoma cell line HepG2 transfected with the full genome of HBV, were collected and concentrated. HLCZ01 cells were seeded into 60-mm plates, and 16 h later, cells were transfected...
Full size image Different mouse models have been used to investigate the function of AE. The knock-in of AE in the endogenous AML1 locus inhibited hematopoiesis, resulting in lethality.24, 25 A conditional AE knock-in approach resulted in enhanced replating capacity of myeloid progenitors without...
'pains and ever save their lives. For another, I have always shown great interest in Chinese medicine, which features magic effect. Should I be admitted by a medical college this year, I would make every effort to rediscover the val...
(public organizations, local governments, universities, enterprises, ngos, citizens and civic organizations, etc.); how to build data-based age-friendly community service design; how to further integrate the health system of ...
full advantage was taken __(10)the aero-plane.__(11)country has proved this ___(12)than Australia.The Australians ___(13) greeter use of the aero-plane than any _(14) people in the word.In no other country __(15)the total number of miles flown by the __...
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