In this scenario, combination therapy of CBD and BDNF could be a fruitful strategy for the treatment of AD. We designed mannose-conjugated chitosan-coated poly(d,l-lactide-co-glycolide (PLGA) (CHTMAN-PLGA) nanoparticles for the codelivery of CBD and BDNF to the brain. Chitosan is modified ...
目的: 探讨通过基因转染技术将脑源性神经营养因子(BDNF)转染到骨髓基质细胞,然后立体定向移植到老年性痴呆(AD)大鼠海马区,观察细胞移植后对AD大鼠海马CA1区突触素(synaptophysin,Syn)表达及学习记忆能力的影响. 方法: 用阳离子聚合物介导法将BDNF基因转染到大鼠骨髓基质细胞(BMSCs)中.免疫组化染色检测转基因骨髓基....
恢复睡眠时间大鼠海马区BDNF及其受体TrkB的mRNA及蛋白水平.结果 RSD1d组海马的BDNF和TrkB mRNA增多(p<0.05),RSD3d组表达达到高峰,RSD5d组BDNF 表达下降,RSD7d组降至基线水平,恢复睡眠组,环境对照组和空白对照组相比差异不显著;蛋白变化显示相同的趋势.结论相对较短时间的睡眠剥夺后BDNF及TrkB的表达增加反映了机体的...
Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF funct... PURPOSE: Interleukin (IL)-1 can activate glial cells to trigger neuroinflammation and neurodegeneration. Lower omega (n)-3 polyunsaturated fatty ac...