Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis JCI Insight, 1 (2016), p. e87336 View in ScopusGoogle Scholar [60] S. Udi, et al. Dual inhibition of cannabinoid CB(1) receptor and inducible NOS attenuates obesity-induced chronic...
A safe and potent CB1 inhibitor would have the potential to block the biological processes induced by supraphysiological CB1 activation and provide a novel treatment to patients. Learn More Pipeline We are building our innovative pipeline with the singular focus to advance peripherally acting CB1r bloc...
The goal of this clinical trial is to evaluate the safety and efficacy of nabiximols, a cannabinoid spray, for the treatment of moderate to severe spasticity in adult patients with AQP4-IgG positive and antibody-negative NMOSD. The main question it aims to answer is whether treatment with nabi...
[6] Zhou X, Yao Z, Bai H, et al. Treatment‐related adverse events of PD‐1 and PD‐L1 inhibitor‐based combination therapies in clinical trials: a systematic review and meta‐analysis[J]. Lancet Oncol, 2021, 22(...
Transient transfection of hepatocytes with a miR-22 hairpin inhibitor reduced the ability of the cells to accumulate fat following exposure to O:P (L) or ACEA (M) treatment. ACEA was unable to reduce the expression of PPARα (N) and SIRT1 (O) in the transfected cells with a miR-22 ...
Steinberg R, Francon D, Alonso R, Avenet P, Oury-Donat F, Perrault G, Griebel G, George P, Soubrie P, Scatton B (2005) Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic....
Systemic pretreatment with the MAGL inhibitor, MJN110, prevented the aversive effects of acute MWD by a CB1 receptor-dependent mechanism. Furthermore, in a double dissociation, AM251 infusions into the central amygdala, but MJN110 infusions into the basolateral amygdala, interfered with the naloxone...
These data demonstrate a biphasic and dose-sensitive role for the cannabinoid system in behavioral flexibility, which in turn may have clinical implications for the role of the endocannabinoid system in psychiatric disorders where behavioral flexibility is compromised. ...
Furthermore, rats treated with AM251 or MJN110–AM251 were significantly less active on the saline trial, but not the MWD trial, than rats that were treated with VEH or MJN110. DISCUSSION Systemic administration of the MAGL inhibitor, MJN110, prevented the establishment of a naloxone-...
1.膜性肾病患者初始治疗前应评估疾病进展风险,并按照风险分层选择免疫抑制剂治疗:对于存在极高进展风险的膜性肾病患者,应使用环磷酰胺(cyclophosphamide, CYC)联合糖皮质激素治疗;对于存在中、高进展风险的膜性肾病患者,可选择RTX或钙调神经蛋白抑制剂(c...