CB-839 是一种有效的,选择性的,口服生物可利用的 glutaminase 抑制剂,对重组人GAC的 IC50 为 24 nM。Phase 1。 体外研究 CB-839 exhibits time-dependent and slowly reversible kinetics. IC50 values for glutaminase inhibition by CB-839 following preincubation with rHu-GAC for-1 hour are < 50 nmol/...
生物活性 CB-839 (Telaglenastat) 是一种有效的,选择性的,口服生物可利用的 glutaminase 抑制剂,对重组人GAC的 IC50 为 24 nM。CB-839(Telaglenastat)可诱导自噬并具有抗肿瘤活性。[1] In Vitro CB-839表现出时间依赖性和缓慢可逆的动力学特性。与rHu-GAC预培养1小时后,CB-839抑制谷氨酰胺酶的IC50值<50...
[CB-839]化源网提供CB-839CAS号1439399-58-2,CB-839MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询CB-839上化源网,专业又轻松。
CB-839 (Telaglenastat) 是一种有效的,选择性的 glutaminase 抑制剂,对重组人GAC的 IC50 为 24 nM。CB-839(Telaglenastat)可诱导自噬并具有抗肿瘤活性。 Biochemical mechanism: Cell permeable: yes Primary Target GLS1 Reversible: yes Target IC50: 23 nM & 28 nM, respectively, using murine kidney and...
中文名CB-839 英文名CB-839 中文别名 英文别名CB839; CB 839;Telaglenastat,; 分子式C26H24F3N7O3S分子量571.57 用途 生物活性CB-839 is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. CB-839 selectively and irreversibly inhibits glutaminase. By blocking glutamine...
CB-839 is a potent and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC), and with IC50 of 23 nM and 28 nM in kidney and brain, respectively. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学研究者提供高品质的产...
Given the central role of glutamine in anabolic and catabolic pathways, we examined the effects of pharmacologically inhibiting glutaminolysis, that is, the conversion of glutamine (Gln) to glutamate (Glu), using CB-839, a small molecular inhibitor of the enzyme glutaminase (GLS). We show that ...
CB-839抑制剂 Telaglenastat (CB-839) 是可口服,非竞争性的谷氨酰胺酶1 (glutaminase 1 (GLS1)) 剪接变体 KGA 和 GAC 的抑制剂,IC50 值分别为 23 nM 和 28 nM。 MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务 IC50和目标:IC50:23 nM(肾脏中的谷氨酰胺酶),28nM(脑中的谷氨...
CB-839, a selective glutaminase inhibitor, has anti-tumor activity in renal cell carcinoma and synergizes with everolimus and receptor tyrosine kinase inhibitors 机译:CB-839,一种选择性的谷氨酰胺酶抑制剂,在肾细胞癌中具有抗肿瘤活性,并与依维莫司和受体酪氨酸激酶抑制剂协同作用 ...
CB-839 (Telaglenastat) 是一种有效的,选择性的 glutaminase 抑制剂,对重组人GAC的 IC50 为 24 nM。CB-839(Telaglenastat)可诱导自噬并具有抗肿瘤活性。 Information Telaglenastat (CB-839) Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24...