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We have used in vivo imaging and transgenic mice expressing fluorescent-tagged occludin and ZO-1 fusion proteins to link occludin endocytosis to TNF-induced tight junction regulation. This endocytosis requires caveolin-1 and is essential for structural and functional tight junction regulation. These ...
TNF-induced endocytosis occurs at occludin-enriched tight junction sites Transgenic mice were use to irect y visua ize tight junction reorganization uring TNF-in uce barrier oss. mRFP1– ZO-1 was use to i enti y the p ane o the tight junction. Very itt e change in either mRFP1–ZO-1...
Integrin endocytosis/recycling has been implicated in the regulation of cell migration. However, the mechanisms by which integrin endocytosis/recycling regulates cell migration, and other biological consequences of integrin trafficking are not completely understood. We previously showed that turnover of ...
4). These results suggest that FiVis entry into murine brain endothelial cells was mediated by caveolin-dependent endocytosis. Fig. 3: Passage of FiVis nanoparticles across the BBB is mediated by Cav1. a–c, Immunofluorescence of Cav1 (white) and CD31 (green) in advanced SHH-MB mouse ...
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER Nat. Cell Biol., 3 (2001), pp. 473-483 View in ScopusGoogle Scholar Pelkmans et al., 2004 L. Pelkmans, T. Burli, M. Zerial, A. Helenius Caveolin-stabilized membrane domains as multif...
We show that caveolins and caveolin dependent endocytosis are necessary for proper gastrulation, most likely by interfering with Wnt5a/Ror2 signaling. Wnt5a regulates the subcellular localization of receptor complexes, including Ror2 homodimers, Ror2/Fzd7 and Ror2/dsh heterodimers in an endocytosis ...
因此, PICK1 增加 Tβ 的调停 caveolin 的 endocytosis, ubiquitination 和降级; RI.而且,在 PICK1 表示和 Tβ 之间的否定关联; RI 或 phospho-Smad2 层次在人的胸肿瘤被观察,显示那 PICK1 可以通过 TGF-β 的抑制参予乳癌开发;发信号.我们的调查结果作为 TGF-β 的一个重要否定管理者揭示 PICK1 的非神经...
Clathrin- and caveolin-dependent endocytosis inhibitors were used at varying concentrations to elucidate the roles of these important pathways. Results PEI and PAMAM polyplexes were internalized by both pathways. However, the amount of polyplex internalized poorly correlated with transgene expression. While...
IGF-I intracellular signalling in the human placenta is dependent on clathrin- and caveolin-dependent endocytosisDuring pregnancy, trophoblasts invade and transform the maternal spiral arteries that supply blood to the placenta. Recent work has revealed that this process occurs in several stages, and ...