胶质瘤细胞中高表达的Cavin1蛋白可以装载至细胞外囊泡,而表达的vCavin1却未在细胞外囊泡中检测到,这表明与Caveolin1的正常结合对于Cavin1募集到细胞外囊泡的重要性。与vCavin1相比,Cavin1不仅增强了胶质瘤来源的细胞外囊泡的分泌,还提高了细胞外囊泡被胶质瘤细胞摄取的速率,并提高了经静脉注射的细胞外囊泡在脑...
的重要调节蛋白.研究表明高糖处理内皮细胞可以改变内皮细胞的稳态,如增加内皮细胞的通透性,诱导内皮细胞凋亡.自噬作为细胞的看家机制在维持细胞的稳态中有着关键性的作用.有研究表明caveolin-1可以负调控自噬,但是 cavin-1在自噬中的作用尚不清楚.本研究的主要目的是研究内皮细胞中cavin-1在自噬中的作用和机制以及...
Caveolae的成分包括小窝蛋白(caveolin),cavin(又叫聚合酶I和转录释放因子),脂类,转录聚合酶和各种各样的离子通道蛋白。Caveolin家族有三个亚型:Caveolin-1(Cav-1),Caveolin-2(Cav-2)和Caveolin-3(Cav-3)。在许多细胞中Cav-1常和Cav-2共表达。Cav-2不是Caveolae组成的必须成分,Cav-2的定位和表达常取决于Cav-1...
Knockdown of Cavin-1 or Cav-1 in the human RD and RH30 cells led to impairment of cell proliferation and migration. Moreover, loss of Cavin-1 in RD cells impaired the anchorage-independent cell growth in soft agar. While the loss of Cavin-1 did not affect the Cav-1 protein levels in...
Caveolae的成分包括小窝蛋白(caveolin),cavin(又叫聚合酶I和转录释放因子),脂类,转录聚合酶和各种各样的离子通道蛋白。Caveolin家族有三个亚型: Caveolin-1(Cav-1),Caveolin-2(Cav-2)和Caveolin-3(Cav-3)。在许多细胞中Cav-1常和Cav-2共表达。Cav-2不是Caveolae组成的必须成分,Cav-2的定位和表达常取决于Cav...
RNAi介导的聚合酶I和转录释放因子(PTRF/Cavin-1)的缺失是维持小窝稳定所必需的一种重要的Cav1外壳成分,也影响了Cav1的部分定位(尽管低于显著阈值),并增加了Cav1的磷酸化(图S1 C),高分辨率显微镜检查证实了在MVB腔内存在Cav1,与...
来自 掌桥科研 喜欢 0 阅读量: 5 摘要: Cavin-1 and BMPR2 competitively interact with the Caveolin-1 scaffolding domain that modulate BMP/Smad signal transduction in pulmonary artery endothelial cells and these interactions are involved in the development of pulmonary hypertension. 年份: 2024 ...
Caveolin-1 exhibits a stage-dependent, functional fluctuation during pancreatic cancer development, but the underlying mechanisms remain unclear. Here, we report that cavin-1, a structural protein of caveolae, modulates the oncogenic function of caveolin-1 and cooperates with caveolin-1 to enhance panc...
This kinase-independent function of ROR1 facilitates the interactions of cavin-1 and CAV1 at the plasma membrane, thereby preventing the lysosomal degradation of CAV1. Caveolae structures and prosurvival signalling towards AKT through multiple RTKs are consequently sustained. These findings provide ...
Neuro-Oncology | 天津医科大学康春生团队发现新的小分子,逆转替莫唑胺治疗胶质母细胞瘤的耐药 2023年8月31日,天津医科大学总医院、天津市神经病学研究所康春生教授课题组在神经肿瘤学知名期刊Neuro-Oncology(影响因子15.9,中科院1区,JCR 1区)发表题为“EPIC-1042 as a potent PTRF/Cavin1–caveolin-1 interactio...