The large selective advantage ofTP53losses are consistent with its roles in arresting the cell cycle or triggering apoptosis upon threats to genome integrity.TP53-null cells better tolerate genomic instability, which can result from endogenous causes, most prominently oncogene-overexpressing and thus repl...
Liver disease incidence is on the rise worldwide, posing an increasing risk of morbidity. Despite intensified global public health interventions, liver diseases continue to represent a significant portion of the global disease burden, underscoring the complexity and multidimensionality of liver disease epid...
Complex post-traumatic stress disorder (C-PTSD) is a mental health condition that can develop after prolonged exposure to traumatic events, often involving interpersonal trauma. Its symptoms go beyond those of regular PTSD and can significantly impact daily life. Here are nine one-liner symptoms of...
APOBEC3 overexpression likely promotes mutagenesis, as multiple studies have identified correlations between APOBEC3 expression and a signature-specific mutation burden (Table1). In a combined analysis of multiple tumor types,APOBEC3Bexpression was strongly associated with a higher APOBEC3-induced mutation...
The effect of chronic stress on striatal function and its relevance to disease Despite scientific evidence linking stress to striatal dysfunction and to motor symptoms worsening/triggering in neuropsychiatric disorders22,27,28,76, the effect of chronic stress on striatal function remains elusive. Deficits...
Missing a meal is one of the most reliable ways of triggering a headache, according to one survey of headache patients. About 30% of patients who have migraine with aura reported this as a trigger. Fasting seems to make things worse, with more than 55% of male migraine patients and 65%...
Think of a phobia as the brain's alarm system in overdrive—it overestimates the threat of a particular situation, triggering intenseanxietyand leading you to avoid that situation in the future. That avoidance actually makes a phobia worse because it solidifies the brain's overblown association...
Missing a meal is one of the most reliable ways of triggering a headache, according to one survey of headache patients. About 30% of patients who have migraine with aura reported this as a trigger. Fasting seems to make things worse, with more than 55% of male migraine patients and 65%...
Suppression of β-cell function by sertraline was involved in inhibiting the increase in cellular reducing power stimulated by glucose, activating endoplasmic reticulum stress, triggering the unfolded protein response and induc- ing β-cell apoptosis[38]. In addition, the expression and func- tion of...
How dengue fever and causes vascular leak and shockThe dengue NS1 protein is thought to play a critical role in severe dengue disease by triggering immune reactions associated with vascular leak and shock, which are the major causes of death in persons suffering from dengue hemorrhagic fever. ...