The binding of NOTCH ligands is regulated by protein O-fucosyltransferase 1 (POFUT1). Bound ligand triggers cleavage of the associated receptor and then release of its intracellular domain (NOTCH intracellular domain, which shuttles to the nucleus where it forms a transcriptional complex with RBPjk...
Post-COVID depression: The unknown side effects of the pandemic What are the emotional triggers for empaths to watch for? Ultra-motivated, but exhausted workers are more common than you think—here’s what to do about it What is mental load? Recognize the burden of invisible labor ...
Converging lines of inquiry from across the social and biological sciences target the adult sex ratio (ASR; the proportion of males in the adult population) as a fundamental population-level determinant of behavior. The ASR, which indicates the relative number of potential mates to competitors in ...
Evaluation of theTP53function loss score classifier and prevalence ofTP53loss phenocopying events in cancer.aReceiver operating characteristic (ROC) curve and area under the ROC (AUROC) curve for training and testing sets in TCGA tumor transcriptomes.bBottom: FDR for each tumor sample. X axis show...
where it triggers the release of a hormone, adrenocorticotrophic hormone (ACTH). ACTH is released into the bloodstream and causes the cortex of the adrenal gland to release the stress hormones, particularly cortisol, which is acorticosteroidhormone. Cortisol increases the availability of the body'...
As much shame as symptoms may trigger, drinking problems are an understandable human predicament. The best strategy is to be frank in response to a doctor's questions.During an office visit, a health care professional will likely focus on the following....
changes in eating or sleeping habits excessive mood swings abnormally high amounts of paranoia or anxiety What is the major cause of mental disorders? The major causes of mental disorders include biological and sociological issues. These issues may also interact with or trigger the development of...
PTSD:Symptoms include flashbacks, nightmares, hypervigilance, avoidance of triggers, and a heightened startle response. C-PTSD:In addition to PTSD symptoms, C-PTSD includes difficulties with emotion regulation, self-esteem, and forming healthy relationships. It may also involve a persistent sense of ...
Chronic stress (CS) is associated with a number of neuropsychiatric disorders, and it may also contribute to or exacerbate motor function. However, the mechanisms by which stress triggers motor symptoms are not fully understood. Here, we report that CS functionally alters dorsomedial striatum (DMS...
there has been a gradual increase in prevalence from 2009 to 2013.97The precise etiology of AIH remains elusive, though there is speculation that environmental changes may act as triggers.88These diseases exemplify the complex interplay of genetic, environmental, and immunological factors that characteri...