QRS prolonged DeliveryIV, PO DosePO: 50–200 mg q 12 h. T1/27–22 h Metab: H Excr: U Adverse effectsCardiac:Sinus node dysfunction, AVB, drug-induced Brugada syndrome, monomorphic VT in patients with a myocardial scar, exacerbation of HFrEF. Flecainide causes increased defibrillation threshol...
Background: Although there are limited data on oxycodone overdose, it has been suggested that, in addition to central nervous system (CNS) depression, oxycodone may cause QT prolongation. Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment...
Demographic information, details of ingestion, clinical effects, ECG parameters [heart rate (HR), QT and QRS], naloxone use and length of stay (LOS) were extracted from a clinical database. QT was measured manually and plotted on a QT nomogram. LOS was extracted for all overdoses over the...
Methods and results: In conscious telemetered mice, acute intraperitoneal and oral administration of azithromycin caused effects consistent with multi-ion channel block, with significant sinus slowing and increased PR, QRS, QT, and QTc intervals, as seen with azithromycin overdose. Similarly, in HL-...
While the zebrafish heart is two-chambered, heart rate, P-wave duration, and PR, QRS and QT intervals are similar to those of humans12,13. A separate transgenic line expressing wild-type (WT) cmlc1 served as a control (WT transgenic). Quantitative PCR showed no statistical difference in ...
Why does QT prolongation cause torsades? Torsade de pointes is widely thought to be triggered by reactivation of calcium channels, reactivation of a delayed sodium current, or a decreased outward potassium current that results in early afterdepolarization (EAD), in a condition with enhanced TDR usua...
Demographic information, details of ingestion, clinical effects, ECG parameters [heart rate (HR), QT and QRS], naloxone use and length of stay (LOS) were extracted from a clinical database. QT was measured manually and plotted on a QT nomogram. LOS was extracted for all overdoses over the...
In LV, RAN did not significantly alter APD90, ERP, DTE, Vmax, and QRS duration (n = 5–6). Our results demonstrate the effect of a relatively low concentration of RAN to suppress induction of AF much more effectively (70%) in an HF model of AF than previously described in vagal ...