In cases of complete erectile dysfunction, in which tissue damage or other physiological problems prevent other solutions (such as Viagra) from being effective, penile implants may be the method of choice. The surgery needed to insert these implants is usually performed on people between the ages ...
Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic autopsy’ as an adjunct to standard autopsy for 200 families who had experienced fetal or newborn death, providing a definitive or candidate genetic diagnosi
J. et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 155, 997–1007 (2013). Article CAS Google Scholar Courchesne, E., Carper, R. & Akshoomoff, N. Evidence of brain overgrowth in the first year of life in autism...
The immunofluorescence of the spermatozoa was performed as previously described.38 The prepared spermatozoa were fixed in 4% paraformaldehyde for 30 min, and permeabilized with 0.2% Triton X-100 for 10 min. The sections were then blocked with 5% fetal bovine serum (FBS) for 60 min and incubated...
Alzheimer’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the mechanism(s) that cause endosome enlargeme
Video S2. Time-Lapse Imaging of Aβ 42 Uptake by Microglia-like Cells Carrying the APOE4 Allele, Related to Figure 4 Video S3. APOE3 Microglia-like Cell-Mediated Aβ Clearance in APP Organoids, Related to Figure 4 Video S4. APOE4 Microglia-like Cell-Mediated Aβ Clearance in APP Organoi...
Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune function, we hypothesize that SCI disrupts bone marrow hematopoiesis. Indeed, SCI causes excessive proliferation of bone marrow hema...
LV. This encouraged us to attempt coil implantation in the LA even earlier (~76 days, 0.52 gestation) and with the potential for a longer duration of low left heart flow (until ~124 days, 0.84 gestation; Fig.1a). These fetal lambs are the subject of this report....
Similarly, a paternal low-protein diet can affect offspring metabolism by increasing expression of many hepatic genes involved in lipid and cholesterol biosynthesis, which correlated with aberrant cytosine methylation in offspring of males fed with a low-protein diet30. In addition, paternally inherited...
We hypothesize that the fetal HSC response to prenatal inflammation drives lasting changes to hematopoietic output in offspring that shapes the postnatal immune response. Here, we use a maternal immune activation (MIA) model to decipher the effects of in utero inflammation on fetal HSPCs, and ...