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and then the local molecular dynamics of the wild-type and E396ter DYRK1A proteins were assessed by using the Dynamut webserver with normal mode analysis function (Fig.2b). As a result, we found that the DYRK1A-E396ter protein had elevated deformation energy throughout the protein compared ...
GABA signaling intensively regulated excitatory output of pyramidal neurons via inhibitory synapses at the axon initial segment, soma, dendritic shaft and spines (Kubota et al., 2016). Increased GABA signaling via enhanced inhibitory synapses and elevated GABA neurotransmitter resulted in the increase of...
response. We all know what this stress response feels like: heart pounding in the chest, muscles tensing up, breath coming faster, every sense on red alert. Understanding Stress: Signs, Symptoms, Causes, and Effects http:/ / .helpguide/ mental/ stress_signs.htm (1 of 11) [ 7/ 10/ 20...
Elevated hs-cTn concentrations have consistently emerged as strong predictors of adverse outcome [2–6]. However, despite the expression of cTnT and cTnI as an obligate 1:1 complex in cardiac tissue [7] and the reasonably well calibration of cTn assays such as those from Roche and Abbott [...
Jia Li2†, Hua Yan2* , Hui Guo2, Dan Song2 and Xi Su2 Abstract Background: Spontaneous coronary artery dissection (SCAD) has emerged as an increasingly diagnosed cause of ST-segment elevation myocardial infarction (STEMI), which is easily missed or delayed....
Atherosclerosis and plaque disruption have a central pathological role in the majority of patients who present with an acute coronary syndrome (ACS), but non-atherosclerotic processes are also important contributors to a substantial number of ACS events and require different diagnostic and therapeutic str...
we revealed that multiple forms of pain sensitivity are markedly increased in a mild SMA mouse model. Using patch-clamp recordings we found hyperexcitability of nociceptive DRG neurons and increase in sodium current densities. Furthermore, we identified a signaling cascade from elevated plasma norepinep...
Caloric intake was elevated and despite the loss of calories due to glucosuria they gained body weight in excess. They phosphorylated AKT and did not develop life-threatening hyperglycemia, nor did they become catabolic even though these mice lacked fully processed insulin. In contrast, a lack of...
segment of the animal. Each AP is comprised of a syncytial epithelium with the apical cell surface directed outwards to the environment, and the basolateral cell surface facing the lumen which is continuous with the haemocoel21. This morphology allows for the direct excretion of ammonia into the...