Signs of central or peripheral volume overload (eg, elevated neck veins, peripheral edema) Dyspnea while lying flat (orthopnea) or appearing 1–2 hours after falling asleep (paroxysmal nocturnal dyspnea) ECG BNP measurement Echocardiography
Elevated pulmonary venous pressure (especially in mitral stenosis, left-sided heart failure) Crackles Signs of central or peripheral volume overload (eg, elevated neck veins, peripheral edema) Dyspnea while lying flat (orthopnea) or appearing 1–2 hours after falling asleep (paroxysmal nocturnal dyspn...
1b). These positive correlations seem to be exclusive for WAT as no changes in RalA levels were detected in BAT after HFD feeding (Extended Data Fig. 1c). Together, these observations support the notion that adipocyte RalA activity is constitutively elevated in obesity. Fig. 1: White ...
Aggregation of particular proteins in the form of inclusion bodies or plaques followed by neuronal death is a hallmark of neurodegenerative proteopathies such as primary Parkinsonism, Alzheimer’s disease, Lou Gehrig’s disease, and Huntington’s chorea. Complex polygenic and environmental factors implic...
Elevated pulmonary venous pressure (especially in mitral stenosis, left-sided heart failure) Crackles Signs of central or peripheral volume overload (eg, elevated neck veins, peripheral edema) Dyspnea while lying flat (orthopnea) or appearing 1–2 hours after falling asleep (paroxysmal nocturnal dyspn...
The partial thromboplastin time (PTT) values were increased in 5% and decreased in 9% of the patients. Calcium levels were elevated in 12% of the patients, whereas magnesium concentrations were within the normal range in all patients. Metabolic markers: The alpha-galactosidase levels were reduced...
Although they typically lack evidence of obesity and insulin resistance, patients will have elevated serum LDL and triglyceride and decreased HDL levels, features that overlap with type 2 diabetes and result in misclassification in diagnosis. Although the initial presentation may be mild to modest ...
cancers Article Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour Tiago Bordeira Gaspar 1,2,3,4 , Sofia Macedo 1,2,3,4 , Ana Sá 1,2, Mariana Alves Soares 1,2,5,6 , Daniela Ferreira Rodrigues 1,...