Absence of elevated MMA and presence of elevated C4DC have occasionally been reported in other patients harboring SUCLA2 mutations.20,21 This elevation is probably also a consequence of succinyl-CoA buildup, which can result in shift of the reversible conversion of succinyl-CoA to C4DC in the...
Glutathione, adenosine and nitric oxide were decreased while uric acid (UA), xanthine oxidase (XO), malondialdehyde (MDA), lactate dehydrogenase activity and free fatty acids were increased in the kidneys of gestational rats exposed to testosterone. Also, plasma urea and creatinine were elevated. ...
This is more likely if blood sugars remain elevated and high blood pressure is not treated aggressively.Diagnosing type 2 diabetesDiabetes is diagnosed by testing the blood for sugar levels. Blood is tested in the morning after you have fasted overnight....
Part I of this two-part series covered gastrointestinal causes of chest pain and aortic dissection. This second and final part of the series will focus on pulmonary, psychiatric, and musculoskeletal causes of chest pain.
Although the proband had CKD, his HDL maintained an elevated cholesterol efflux capacity compared with HDL of the normolipidemic control (Fig. 4b), whereas the antioxidative activities of total HDL and small, dense HDL3c were similar between the proband and the normolipidemic control subject (...
When exposure to excess iodine is suspected (e.g., when the RAIU is lower than expected from the clinical history), assessment of urinary iodine concentration (spot urine iodine adjusted for urine creatinine concentration or a 24-hour urine iodine concentration) may be helpful. The uptake over ...
The latter gene encodes a protein that is predicted to function as a carbohydrate kinase. Cystinosis patients with the common 57-kb deletion had strongly elevated urinary concentrations of sedoheptulose (28–451 mmol/mol creatinine; controls and other cystinosis patients <9) and erythritol (...
Moreover, the protein levels of FXRα, RXRα, LRH-1, HNF4α, and SHP were also significantly reduced in Tmem30a-deficient livers (Figure 3C). ATP8B1 has been shown to regulate the FXRα pathway by down-regulating the phosphorylation of protein kinase C (PKC)ζ.31, 32, 33, 34, 35 ...
Serum biochemistry values were retrieved from the DPCK’s information system and included alkaline phosphatase (ALP), serum bilirubin, creatinine kinase myocardial band (CKMB), C-reactive protein (CRP), D-Dimer, estimated glomerular filtration rate (eGFR CKD-EPI), ferritin, gamma-glutamyl transferase...
Patients with associated NTHPs had elevated bilirubin (p<0.0001), serum creatinine (p=0.0005), and an increased international normalized ratio (p<0.0001). In contrast, serum lactate dehydrogenase remained comparable. The requirement of frequent hospital admissions and intensive care unit (ICU) ...