Using an insulin clamp, the most reliable method for measuring insulin resistance, the scientists saw that the subjects with type 2 diabetes had higher insulin resistance than those with type 1 or no diabetes at all. They also noted a correlation between insulin resistance and the levels of a ...
Interview: The cause of Type 2 diabetes: a new paradigmShuichi Kaneko
糖尿病的病因(Thecauseofdiabetes) I.geneticfactors Diabeteshasbeenrecognizedasageneticdisease,andgenetic studieshaveshownthattheincidenceofdiabetesis significantlydifferentfromthatofnonrelativesamong relativesofdescent,theformerbeing5timeshigherthanthe latter.Theimportanceofgeneticfactorswas50%inthe etiologyoftype1dia...
Type 2 diabetes has long been thought to have heterogenous causes, even though epidemiological studies uniformly show a tight relationship with overnutrition. The twin cycle hypothesis postulated that interaction of self-reinforcing cycles of fat accumulation inside the liver and pancreas, driven by mode...
PURPOSE OF REVIEW: It is the current opinion that pathogens, such as viruses, are contributing to the development of type 1 diabetes (T1D) in susceptible individuals. This opinion is based on epidemiological associations, direct isolation of pathogens from the islets of Langerhans, as well as a...
Second, it was not possible to determine the prevalence of type 1 diabetes. However, based on age at diagnosis (<30 years) and insulin use, less than 1% of cases were likely to have been type 1 diabetes. Future studies are also needed to confirm whether diabetes detected by different ...
The median time (interquartile range) from first hypoglycemia event to first CV event was 1.5 years (0.5, 3.5 years) and 1.5 years (0.5, 3.0 years), respectively, for people with type 1 and type 2 diabetes. CONCLUSIONS: Hypoglycemia is associated with an increased risk of CV events and ...
Scientists at Washington University School of Medicine in St. Louis working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes.
The prevalence of cardiometabolic syndrome (CMS) shows a tendency to increase, mirroring the increases observed in obesity and type 2 diabetes, attributed to the prevalence of high-calorie, low-fiber diets, decreased physical activity, and prolonged sedentary behavior [1,2,3]. According to the Na...
Cardiovascular disease was the leading cause of death among the over 16,000 patients with type 2 diabetes who were enrolled in the SAVOR-TIMI 53 trial.