Lysosomes are membrane-enclosed organelles that break down various macromolecules and are key regulators of cellular metabolism. For the proper degradation of substrates, lysosomal enzymes need an appropriate ionic environment characterized by acidic pH (1, 2) and high Cl− concentration (3, 4, 5,...
The main arteries involved in gut blood supply include the celiac artery, the superior mesenteric artery, and the inferior mesenteric artery. The celiac artery supplies blood to the stomach, spleen, liver, and parts of the esophagus and duodenum. The superior mesenteric artery supplies blood to th...
We defined hypertension as a systolic blood pressure≥140 mmHg, a diastolic blood pressure≥90 mmHg, or having a clinical diagnosis of hypertension and currently prescribed an antihypertensive medication; diabetes mellitus (DM) as an HgA1C ≥ 7.0%, or having a diagnosis of diabetes and currently ...
MBTPS2 missense mutations in two independent kindreds with moderate/severe OI cause substitutions at highly conserved S2P residues. Mutant S2P has normal stability, but impaired functioning in regulated intramembrane proteolysis (RIP) of OASIS, ATF6 and SREBP transcription factors, consistent with ...
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When the homeostatic mechanisms of the gut, which regulates gastro- intestinal Mn absorption, and/or the liver, which modulates the biliary excretion of Mn, fail, get bypassed or are overwhelmed, rising Mn blood levels subsequently result in Mn deposition in the brain6,7. Mn overexposure can ...
35 External cardiac massage Adrenaline Thymoglobulin infusion 124 stopped PaCO2 (mmHg) SpO2 (%) Not intubated 94 39 98 32 99 24 95 ATG thymoglobulin, bp blood pressure, HR heart rate, MAP mean arterial pressure, PaCO2 partial pressure of CO2, SpO2 haemoglobin oxygen saturation Brabant et al....
ROS (reactive oxygen species) is a major type of free radicals in cells and is normally produced during oxidative phosphorylation in mitochondria [14]. Up to 2% of the electrons passing the electron transport chain escape and reacts with molecu- lar oxygen to yield ROS. Due to their high ...
Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permiss
To assess the predictive power of preoperative immune-nutritional scoring systems for patient outcomes in cases of RGC.The clinical records of 54 individuals diagnosed with RGC were methodically reviewed and analyzed in a retrospective manner. From preoperative blood indicators, namely absolute lymphocyte ...