The mRNA and protein expression of cationic amino acid transporter-1 (CAT-1) were determined in FLSs isolated from RA and OA patients by real-time PCR and western blotting. MTT assay, cell cycle, apoptosis, invasion, and cytokine secretion were determined in FLSs knocked down of CAT-1 using...
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Her
While L-homoarginine has already been used for over 35 years as a competitive inhibitor of the y+-mediated transport of cationic amino acids20, its interaction with individual components of this system (i.e. CAT1, CAT2A and CAT2B) still remained to be elucidated. The present study indicates...
The following CPPs, TAT, MAP (KLALKLALKALKAALKLA), Penetratin (RQIKWFQNRRMKWKK), Transportan (GWTLNSAGYLLGKINLKALAALAKKIL), R9 (RRRRRRRRR), were synthesized in the retro-inverso conformation (and also in the natural L-amino acid conformation in the case of TAT). They were labeled ...
1. Introduction In cancer treatment, chemotherapy remains one of the most reliable treatments for many cancers. However, one of the major challenges in chemotherapy is the multi-drug resistance (MDR) by cancer cells caused by the over-expression of drug transporter proteins, especially P-glycoprotei...
The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are for example ligands that can bind to the human transporter of cationic L-amino acids (hCAT1). Such hCAT1 binding molecules find ...
The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are for example ligands that can bind to the human transporter of cationic L-amino acids (hCAT1). Such hCAT1 binding molecules find ...
We present here a model of an inborn aminoaciduria, lysinuric protein intolerance (LPI), in which a single mutation in y+LAT1 cationic amino acid transporter gene SLC7A7 leads to a multisystem disease characterized by immunological complications, life-threatening pulmonary alveolar proteinosis and ...
(Fig.1b). Subsequently, the neuronal glutamine transporter fromRattus norvegicus, the sodium-coupled neutral amino acid transporter, and intracellular vacuolar amino acid transporters 2 (AVT2) and 6 (AVT6) fromS. cerevisiaewere found to be high-scoring hits in a BLASTP search of the TCDB ...
Hydroxyapatite (HAp, Ca10(PO4)6(OH)2, Ca/P = 1.67) is widely employed in biomedical sector, particularly in dentistry and orthopedics, due to its chemical similarity to the mineral component of hard tissue. However, the biological apatite, whose bone and