Caspofungin is a new echinocandin antifungal agent. It has several positive attributes, which may make it a very important therapeutic alternative. First, it has a novel mechanism of action. It inhibits 1,3-芒-D-glucan synthase, an enzyme essential for maintaining fungal cell wall integrity. ...
Caspofungin is a valuable new antifungal agent with a novel mechanism of action. In comparative clinical trials, caspofungin was no less effective than liposomal amphotericin B in the empirical treatment of neutropenic patients with persistent fever, amphotericin B deoxycholate in the treatment of invasiv...
Caspofungin is a medication within the echinocandins class designed to enhance the management of a spectrum of medical conditions. This comprehensive program discusses the intricacies of caspofungin's application, addressing conditions ranging from febrile neutropenia to various candida infections, invasive can...
Caspofungin is a valuable new antifungal agent with a novel mechanism of action. In comparative clinical trials, caspofungin was no less effective than liposomal amphotericin B in the empirical treatment of neutropenic patients with persistent fever, amphotericin B deoxycholate in the treatment of ...
This mechanism of action is different from those of amphotericin B and the azole compounds. For this reason, combination therapy of caspofungin and other antifungal agents has been suggested and has synergistic effects against at least some cryptococcal species. Caspofungin has shown higher therapeutic ...
Caspofungin acetate is a new echinocandin antifungal agent with a mechanism of action that targets a structural component of the fungal cell wall. Objective: This article describes the pharmacologic properties and potential clinical usefulness of caspofungin. Methods: Relevant information was identified ...
Moreover, their mechanism of action is only partially elucidated, making a successful lead optimization and development of more potent analogues uncertain. We set out to identify, amongst already approved drugs, compounds that would act on extracellular matrix to increase antibiotic activity against ...
Mechanism of action Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase. Pharmacokinetics Cmax...
Echinocandins – structure, mechanism of action and use in antifungal therapy The action of echinocandins is based on the inhibition of 尾-(1,3)- d -glucan synthesis that builds the fungal cell wall. Caspofungin, micafungin, ... M Szymański,S Chmielewska,U Czyewska,... - 《Journal of ...
permeabilizationmechanismitisnotclearifthisisthesingle overridingmodeofactionorifotherprocesses are involved in a-hederin cytotoxicity. In the present study we use yeast haploinsufficiency profiling to assess a-hederin activity in a library of yeast strains knocked-down for virtually all essential...