《Caspase-3剪切白血病相关蛋白AML1-ETO的生物学意义》是依托上海交通大学，由卢莹担任项目负责人的面上项目。项目摘要 染色体t (8; 21)易位产生的AML1-ETO融合基因在M2型急性髓系白血病(AML)的发生中起了重要作用，但它的单独存在并不足以引起白血病，提示可能需要 第二次打击。最近，本课题组报道AML1-ETO的...
Caspase is an enzyme with a name pronounced as ['kæspəz] in English and ['kæspəz] in American English. It is formally known as cysteinyl aspartate specific proteinase. Caspase enzymes are a family of cysteine proteases found in the cytoplasm of cells, ...
《靶向caspase-3蛋白酶药物体内筛选及评价体系的建立》是依托中国人民解放军军事科学院军事医学研究院，由张玉华担任项目负责人的青年科学基金项目。中文摘要 缺乏理想的可以实时观测肝细胞凋亡的小动物实验模型, 不便于靶向caspase-3蛋白酶药物体内筛选及评价。本研究拟构建以荧光素酶为报告基因反映caspase-3蛋白酶活性的...
The Caspase family belongs to the cysteine protease group and is structurally similar to the ced-3 protein found in nematodes. These proteases are characterized by their specific cleavage after aspartate residues, which led to their naming as caspases (cysteine aspartate-specific proteases)...