Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer. Gastric Cancer. 2011;14(4):317–21. : 10.1007/s10120-011-0045-1 .Liamarkopoulos E , Gazouli M , Aravantinos G , Tzanakis N , Theodoropoulos G , Rizos S , Nikiteas N . Caspase 8 and caspase...
Thus, we provide evidence that caspase-3 activity is dispensable for MMC-induced apoptosis and for caspase-8 and -9 processing in MCF-7 cells. 展开 关键词: caspase-3 caspase-8 caspase-9 Bcl-2 mitomycin C MCF-7 DOI: 10.1038/sj.cdd.4401062 被引量: 284 ...
It was found that JEV activated the initiators caspase-8 and -9, as well as effector caspase-3, in infected baby hamster kidney and mouse neuroblastoma (N18) cells. In neuronal N18 cells, JEV infection triggered cytochrome c release from mitochondria, which in turn activated caspase-9 and -...
As an important indicator of resistance to chemotheraputic agents, the Bcl-2/Bax ratio showed a significant increase in both MCF-7/Pac5nM and MCF-7/Pac 64nM cells (p<0.001), while caspase-9 levels were decreased (p<0.001) and caspase-8 was increased (p<0.001). FACS analysis ...
overexpressed ILK enhanced apoptosis after irradiation by combined activation of caspase-3 through caspase-8 and -9 in irradiated FN cultures. Irradiation of ILK suspension cultures lacked caspase-8 activation, but showed serial cleavage of caspase-9, -3 and poly (ADP-ribose) polymerase. These find...
在程序性细胞死亡、细胞凋亡、细胞焦亡和坏死性凋亡以及炎症反应中，Caspase家族扮演着重要角色。人类体内已鉴定出11种不同的Caspase，其中参与细胞凋亡的主要有启动Caspase（包括Caspase 8、9和10）和效应Caspase（包括Caspase 3、6和7）。启动Caspase在细胞凋亡过程中被招募到特定复合体（如死亡诱导信号复合...
By applying TRAIL in AM-1 cells, ameloblastoma cell line, for 24 h, we found that TRAIL cleaved caspase-8, -9 and –3, and lowered mitochondrial membrane potential (Δψm), and markedly induced apoptosis in AM-1 cells (46%). These results suggested that TRAIL ...
with caspases cleaving and activating other caspases that subsequently degrade cellular targets that lead to cell death. The activating caspases include caspase-8 and caspase-9. Caspase-8 is the initial caspase activated in response to receptors with a death domain that interacts with FADD...
SA and SB abolished the UVB-mediated cleavage of caspase-3, caspase-8 and caspase-9 levels in HaCaT cells.Wei, HouWei, GaoDatao, WangQingxiu, LiuSiwen, ZhengYingping, Wang
Inhibitors of the post-proline-cleaving serine proteases DPP8 and DPP9 trigger a lytic form of programmed cell death called pyroptosis by activating pro-caspase-1 without autoproteolysis. Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post