Caspase-8是启动者Caspases的重要代表,可通过与连接分子FADD的结合而活化,将凋亡信号传递到下游的效应Caspases分子。Caspase-14是该家族中的最新成员,主要表达于胚胎细胞中,成年期缺乏表达,由于分子结构中没有NH2-末端域,因此又被称为MICE(mini-ICE)。功能研究发现它能直接诱导细胞凋亡,但具体的信号转导途径高不清楚[...
phagocytophilum infection due to the absence of IL-18 secretion and reduced IFN-γ levels in the peripheral blood. Moreover, caspase-1 and ASC deficiency reduced CD4+ T cell-mediated IFN-γ after in vitro restimulation with A. phagocytophilum. The NLR family member IPAF/NLRC4, but not NAL...