通过RCSB Protein Data Bank数据库(https://www.rcsb.org/)查找Caspase-1/GSDMD/NRP3蛋白的晶体结构,筛选条件物种设置为人类,蛋白-配体复合物分辨率低于0.3 nm,将选中的蛋白-配体晶体机构下载保存。利用PyMOL软件对蛋白质进行去水、去...
Synonyms OSIL antibody; Oxidative stress induced like antibody p60 antibody p62 antibody p62B antibody Paget disease of bone 3 antibody PDB 3 antibody PDB3 antibody Category Autophagy Background Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress...
首先从蛋白质结构数据库(protein data bank,PDB)数据库(https: //www.rcsb.org)中检索关键靶点蛋白信息,根据蛋白结构的分辨率、完整性、结合口袋的形状、大小和化学性质以及蛋白结构的共晶配体等相关信息,确定蛋白结构。利用PyMOL软件去除...
Mapping the susceptible Met residues in the 3D structure of procaspase-3 (PDB code: 1I3O, a.a. 32–174 and 176–277)33 shows that Met-39 and Met-44 cluster together at the surface of each monomer (Figure 6). In contrast, the active site Cys-163 is located at the interface of ...
muricata. The prediction process was followed by pharmacophore modelling and molecular docking simulations on caspase-3 (PDB: 1NME) as the target protein and 2-hydroxy-5-(2-mercaptoethylsulfamoyl)- benzoic acid as the natural ligand using AutoDockTools 1.5.6. Res...
The coordinates of caspases-3, -7, -8, and -9 were obtained from the Protein Data Bank (PDB) (codes 1PAU, 1F1J, 1F9E, and 1JXQ). Water was removed from the PDB files. The crystal structures of caspases-3, -7, -8, and -9 include coordinates of Ac-DEVD-CHO, Ac-DEVD-CHO...
(c,d) Molecular surface representation of the crystal structure of GIRK2 homotetrameric channels alone (c, shown in blue) or complexed with Gβγ (d, shown in green) viewed from the side, top, and bottom (Protein Data Bank (PDB): 4kfm). Residues in red show caspase-3 cleavage site...
caspase-11 (C254A)-p22/p10 结构(PDB ID 代码 6KMU)用作小鼠 CASP11 (p22/p10) 模型。基于全长鼠 GSDMD(PDB ID 代码 6N9N)的结构,程序 Modeler 生成了带有切割接头的全长 mGSDMD 中鼠 GSDMD-N 片段的失活构象(mGSDMD-Ni)。此外,基于小鼠 GSDMA3(PDB ID 代码 6CB8)和人类 GSDMD(PDB ID 代码 ...
The electron density maps of caspase-4–pro-IL-18 at 3.2 Å have been deposited at the Electron Microscopy Data Bank (EMDB) under accession code EMD-40678. The atomic coordinates for caspase-4–pro-IL-18 have been deposited at the PDB under accession code 8SPB. Atomic coordinates ...
Protein Preparation: X-ray crystallographic structures of Caspase-3 (PDB ID: 1NME), creatinine kinase (CK) (PDB ID: 1I0E) high-sensitivity C-reactive protein (PDB ID: 3I2Y), and B-cell lymphoma 2 (Bcl2) (PDB ID: 4AQ3) retrieved from the RCSB Protein Data Bank36. ...