Deficiency of caspase 3 either in tumor cells or in tumor stroma caused substantial tumor sensitivity to radiotherapy in xenograft or mouse tumors. In human subjects with cancer, higher amounts of activated caspase 3 in tumor tissues are correlated with markedly increased rate of recurrence and ...
Celecoxib and paclitaxel synergistically induce apoptosis in the human ovarian cancer cell line OVCAR-3 Caspase-3 was evaluated using the Caspase-3/CPP32 Colorimetric Assay kit. Caspase-9 and cleavage of poly ADP-ribose polymerase (PARP) were determined by... H Kim,G Yim,Y Kim - 《...
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation. Both apoptosis and pyroptosis are caspase-dependent programmed cell death pathways. Cysteinyl as...
Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought to investigate the prognostic potential of caspase-3 and -8 in breast cancer, as well as the ...
乳腺癌中caspase3和caspase9的表达及其意义
in tumor cells, the DNA methyltransferase inhibitor Decitabine could inhibit the hypermethylation of its promoter, thus further promoting the pyroptosis of tumor cells4,5,6. This review will summarize and discuss the potential effects of caspase-3 dependent cell death on cancer and the side effects...
antibody. Caspase-3 expression in cancer cells of primary foci was compared with the clinicopathological features of gastric cancer. The apoptosis index (AI) of the abpve-mentioned specimens was studied by TUNEL method. Results：There was high immunohistoreactivity to caspase-3 in epithelial cells...
Recent studies have shown that apoptotic tumor cells stimulate the repopulation of tumors from a small number of surviving cells by cleaved caspase-3 regulation and elevated tumor cleaved (and thus activated) caspase-3 expression levels predict worse treatment outcomes in cancer patients. The ...
Expression of Survivin gene in human non-small-cell lung cancer: association with Caspase-3 and Bcl-2 Purpose: To investigate the expression of Survivin gene and its relationship with expression of Caspase-3, B-cell lymphoma-2( Bcl-2) in human non-small-cel... Y Feng,T Lin,Q Chen - ...
Calcium-independent phospholipase A2 (iPLA2) plays a pivotal role in phospholipid remodeling and many other biological processes, including inflammation and cancer development. iPLA2 can be activated by caspase-3 via a proteolytic process in apoptotic cells. In this study we identify novel signaling ...