Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. Oncogene, 2002, 21 (13): 2108-2113Katsuda,K., Kataoka,M., Uno,F., Murakami,T., Kondo,T., Roth,J.A., Tanaka,N. and Fujiwara,T. (2002) Activation of ...
caspase-3 cleaves the inhibitor, allowing the nuclease to cut the chromatin. Blebbing is orchestrated via the cleavage and activation ofgelsolin(Kothakota et al., 1997), p21-activated kinase-2(Lee et al., 1997; Rudel & Bokoch, 1997), and most likely through cleavage offodrin(Martin et al...
activation of the apoptotic caspase-3 in the absence of inflammatory caspases could serve to induce secondary necrosis through cleavage of DFNA5. Therefore, in addition to it being involved in secondary necrosis, the DFNA5 pathway might also serve as a backup pathway in the events of inflammasome...
在化疗药物如Topotecan、Etoposide等作用下,GSDME通过Caspase-3的切割作用获得活性,诱导肿瘤细胞发生焦亡,这一研究表明GSDME可能成为抑癌基因新方向;同时该研究也发现敲除正常细胞中GSDME的表达能降低化疗药物副作用,为肿瘤的临床治疗提供了新的靶点和思路[17]。
Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells[J]. Cell Death Dis, 2019, 10(3):193. [47]DING Q, ZHANG W, CHENG C, et al. Dioscin inhibits the growth of human osteosarcoma by inducing...
Immunoblotting analysis also showed that the cleavage of procaspase-3 (p20) was detected in HRPE cells in activated co-cultures (Fig. 3B). When the co-cultures were incubated for 24 hours with Z-DEVD-fmk, a caspase-3 inhibitor, caspase-3 activation was significantly inhibited by 80% (...
Recently, several sorts of noninvasive reporters to monitor caspases activation have been developed. One method is the use of fluorescence resonance energy transfer (FRET) pairs linked by peptides containing caspases cleavage sequences, such as DEVD for caspase-3 and -7. This sort of reporter ...
Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175. 靶标信息 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-...
Caspase-3 抗体成分亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,叠氮化钠<0.02% 保存条件-20℃保存 背景资料This Caspase-3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell...
increased serum creatinine and BUN (Fig.1E, F). HE staining exhibited severe renal tubular epithelial cell death in cisplatin-treated mice compared to the control mice (Fig.1G). Western blot detection indicated that cisplatin increased the cleavage of GSDME and caspase 3 activation (Fig.1H–J)...