Caspase-3 Activation Downstream from Reactive Oxygen Species in Heat-Induced Apoptosis of Pancreatic Carcinoma Cells Carrying a Mutantp53Gene Sasaki M,Watanabe N.Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic carcinoma cells carrying a mutant p53... ...
Abstract. Objectives: Nuclear factor-kappa B (NF-κB) activation has been associated with the tumorigenic growth of hepatitis B virus X protein (HBx)-transformed cells. This study was aimed to find a key target for treatment of HBx-mediated cancers. Materials and methods: NF-κB activation, ...
resulting in the formation of two active subunits. These proteases are crucial enzymes in the process of apoptosis, and their activation triggers a cascade of proteolytic events. Activated enzymes within the cell can degrade essential proteins, leading to the irreversible commitment of the...
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Furthermore, enhanced endoplasmic reticulum stress-mediated activation of caspase-3 in endothelial progenitor cells might be involved in hyperhomocysteinemia-associated vascular pathology. 展开 关键词: homocysteine endothelial progenitor cells apoptosis endoplasmic reticulum stress ...
Caspase-3 is processed into an active form (p20 or p17 and p12) during apoptosis. We investigated the relation between caspase-3 and Bcl-xL during development by examining activation of caspase-3 and apoptotic cells in Bcl-x-deficient (bcl-x(-/-)) mice at embryonic (E) day 11.5. We ...
Caspase-3 Activation in HRPE Cells Induced by Activated Monocytes We examined the involvement of caspase-3 in IFN-γ–activated monocyte-induced HRPE cell apoptosis. We quantitated caspase-3 activity in HRPE cell lysates by measuring the cleavage of the caspase-3–specific substrate Ac-DEVD-pNA....
As it did in wild-type cells, G-Rh2 induced the proteolytic activation of caspase-3 protease and subsequent cleavage of PARP in the bcl-2 transfectants. In summary, G-Rh2 contains an apoptotic inducing activity in SK-HEP-1 cells which functions via Bcl-2-insensitive activation of caspase-3...
Sustained calcium (Ca2 þ ) signals and caspase-3 activation in thymocytes were induced by interaction with antigen-pulsed dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine. NMDARs were transiently activated, triggered the sustained Ca2 þ signal and were co...