Inflammasome formation culminates in caspase-1 activation, which causes the cleavage of pro-IL-1尾 and pro- IL-18 into active cytokines; this eventually results in the induction of an inflammatory cell death called pyroptosis. Recent data using Gram-negative bacteria suggests a role for caspase-...
2022年4月29日,来自美国康奈尔大学的Julien Moretti及其团队在Nat Immunol (IF: 20.479)杂志上发表名为Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome的研究[1]。 主要结果 mRNAb...
Caspase-11 is a cytoplasmic sensor of bacterial LPS. Upon binding LPS [153–155], caspase-11 can oligomerize into an inflammasome without the need for upstream NLRs and become proteolytically active, resulting in gasdermin D cleavage, pyroptosis, and release of the alarmins IL-1α and HMGB1 [...
2022年4月29日,来自威尔康奈尔医学院炎症性肠病研究所的微生物学和免疫学教授Julie Magarian Blander研究团队在Nature immunology杂志发表了文章“Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome”,从活的革兰氏阴性细菌中检测到vita-PAMP mRNAbac协同LPS可触发NLRP3...
Broz, P. et al. Caspase-11 increases susceptibility toSalmonellainfection in the absence of caspase-1.Nature490, 288–291 (2012) ArticleADSCASPubMedPubMed CentralGoogle Scholar Rathinam, V. A. et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.Cell...
It has long been presumed that caspase-11 is pro-inflammatory because of its homology to caspase-1, but its actual role has been enigmatic. Vishva Dixit and co-workers now report a crucial role for caspase-11 in inflammasome activation by various pathoge
death 浅谈细胞焦亡 02:31 【中英字幕】Tumor Eradication through nPD-L1-mediated Pyroptosis 01:30 细胞焦亡-Pyroptosis in antibacterial and antitumor immunity-邵峰 【英文字幕】 1:26:25 【中英字幕】细胞焦亡机制graphical abstract,Dave教授带你了解焦亡 11:58 【中英字幕】What is an Inflammasome(炎症小体)...
Caspase-11 Non-Canonical Inflammasome: Emerging Activator and Regulator of Infection-Mediated Inflammatory Responses Inflammation is a body鈥檚 protective mechanism to eliminate invading pathogens and cellular damaging signals. The inflammatory response consists of two ma... YS Yi - 《International Journal...
2015年11月9日 讯 /生物谷BIOON/ --炎性caspase家族蛋白——包括caspase1,4,5,11(其中4,5存在于人中),对于免疫反应的信号传递起到了关键的作用。它们是组成'炎症小体'(inflammasome)的重要元件,后者介导了多种促炎性分子(pro-IL-1beta,pro-IL-18)的表达与分泌。
Inflammasome Activation TriggersCaspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA VirusInfection 文献摘要: 病毒感染会诱发宿主的天然免疫应答,产生各种细胞因子,例如IFN-I,激活炎性小体,触发感染细胞的程序性死亡。严格调控炎性细胞因子的产生对于控制感染的同时又不损伤宿主,有着重要的意义。作者研...