part of the active enzyme. Active caspase 1 contains two heterodimers of p20 and p10. It interacts with another CARD domain containing protein called PYCARD (or ASC) and is involved in inflammasome formation and activation of inflammatory processes.Caspase 1 has been shown to induce cell necros...
Caspase 1活性检测试剂盒(Caspase 1 Activity Assay Kit)是采用分光光度法检测细胞或组织裂解液中caspase 1酶活性或纯化的caspase 1酶活性的试剂盒。Caspase (Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。Caspase 1也称interkeukin1β conberting enzyme (ICE),有时被写作cas...
重组人Caspase-1蛋白蛋白产品,又称Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, IL-1 beta-converting enzyme, p45.其对应NCBI基因号为834,NCBI基因别称为CASP1;该基因种属来源为人源,对应Accession号为NP_150634.1.该蛋白产品又称Active Human Caspase-1, Active Caspase-1, Caspase-1 Enzyme,...
Caspase 1活性检测试剂盒(Caspase 1 Activity Assay Kit)是采用分光光度法检测细胞或组织裂解液中Caspase 1酶活性或纯化的Caspase 1酶活性的试剂盒。Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。Caspase 1 也称interkeukin 1b conberting enzyme(ICE),有时被写作...
Caspase 1也称interkeukin 1b conberting enzyme(ICE),有时被写作caspase-1或caspase 1,是caspase家族中*可以剪切IL-1b前体蛋白或IL-18前体产生相应成熟的细胞因子的caspase。Caspase 11可以剪切45kD的caspase 1前体蛋白,产生20kD和10kD的片段,这两个片段可以形成异源二聚体(heterodimer),并进一步由两个异源二聚...
产品名称:Caspase 1活性检测试剂盒(分光光度法) 规格50Assays 英文名称:Caspase 1 Activity Assay Kit(Colorimetric Method) 货号:E-CK-A381 检测原理 Caspase 1也称interkeukin 1β conberting enzyme (ICE),是caspase家族中 可以剪切IL-1β前体蛋白或IL-18前体产生相应成熟的细胞因子的caspase。Caspase 11可以剪...
人们发现哺乳类细胞中存在着Ced3的同源物ICE(interleukin-1b converting enzyme),它催化白介素-1b的活化,即从其前体上将IL-1b切割下来。在大鼠成纤维细胞中过量表达ICE和Ced3都会引起细胞凋亡,表明了ICE和Ced3在结构和功能上的相似性;然而敲除ICE基因的小鼠其表现型正常,并未发现细胞凋亡发生明显改变。进一步的...
Interleukin-1Enzyme Inhibitors炎性肠疾病白细胞介素1An imbalance of T helper cell type 1 (Th1) versus type 2 (Th2) polarization in favor of Th1 cell subsets appears to be a key pathogenic mechanism in chronic inflammatory bowel disease (IBD), in particular in Crohn's disease. The interferon...
that dimerize to form the active enzyme. Caspase 1 (cleaved Asp297) was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. Caspase 1 (cleaved Asp297...