We identified one target protein as caseinolytic protease P (ClpP), a highly conserved protease in both eukaryotic and prokaryotic cells, playing an essential role in global cellular metabolism regulation. We examined the binding site of c-di-GMP with ClpP and demonstrated that c-di-GMP ...
Caseinolytic protease P (CLPP) is a mitochondrial specific protein which has been reported to be related to tumor cell apoptosis. This study aims to explore the roles of CLPP in human epithelial ovarian cancer (EOC).#We determined CLPP expression in paracancerous tissues and cancer tissues obta...
Plant plastidic caseinolytic protease (Clp) is a central part of the plastid protease network and consists of multiple subunits. The molecular functions of many Clps in plants, especially in crops, are not well known. In this study, we identified an albi
human ClpPproteolysisCaseinolytic proteaseP (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific unfolded protein response (UPRmt). However, its detailed function and dedicated regulation remain largely ...
Caseinolytic proteaseP (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria-specific unfolded protein response (UPRmt ). However, its detailed function and dedicated regulation remain largely unexplored. A small...
Background/ Aims: Antibodies to caseinolytic protease P 177–194 (ClpP 177–194) of the proteolytic subunit of the Clp complex of Escherichia coli ( E. coli) are uniquely present in primary biliary cirrhosis (PBC). Molecular mimicry between the regulatory subunit ClpX and the principal T-...
Use of caseinolytic protease P (ClpP) function and/or concentration as a biomarker for predicting the response of a neoplastic disease, preferably cancer or another disease where enhancing ClpP activity may provide a therapeutic benefit, to a compound of Formula I. In other aspects it relates ...
(2013) The mechanism of caseinolytic protease (ClpP) inhibition. Angew. Chem., Int. Ed. 52, 3009-3014.Gersch M, Gut F, Korotkov VS et al (2013) The mechanism of caseinolytic protease (ClpP) inhibition. Angew Chem 52:3009–3014...
The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix peptidase X (ClpX) and caseinolytic protease P (ClpP) and mediates the degradation of misfolded, damaged, and oxidized proteins, is essential for maintaining mitochondrial homeostasis. ClpXP has been ...
The plastidic caseinolytic protease (CIp) of higher plants is an evolutionarily conserved protein degradation apparatus composed of a proteolytic core complex (the P and R rings) and a set of accessory proteins (ClpT, ClpC, and CIpS). The role and molecular composition of Clps in higher ...