The function of articular cartilage as a weight-bearing tissue depends on the specific arrangement of collagen types II and IX into a three-dimensional organized collagen network that can balance the swelling pressure of the proteoglycan/ water gel. To determine whether cartilage engineered in vitro ...
- 《Journal of Tissue Engineering & Regenerative Medicine》 被引量: 42发表: 2010年 Effects of Seeding Density on Proteoglycan Assembly of Passaged Mesenchymal Stem Cells Cartilage repair strategies have utilized a wide range of cell types at a similarly wide range of seeding densities, both of ...
The elastic (Young’s) modulus of the hESC-derived cartilage tissue constructs (0.91 ± 0.08 MPa) was comparable to full-thickness human articular cartilage (0.87 ± 0.09 MPa). Moreover, we have successfully scaled up the size of the scaffold-free, 3D hESC-derived cartilage ...
(一)软骨组织(chondraltissue)1．软骨细胞(chondrocyte)LM位于软骨陷窝(cartilagelacuna)内,细胞为扁圆形圆形或椭圆形,核小,胞质嗜碱性;可见同源细胞群(isogenousgroup)。EM可见丰富的粗面内质网和高尔基复合体,少量线粒体。功能分泌软骨基质。透明软骨.ppt Chondrocytes LM:Chondrocytesarelocatedincartilagelacuna.Theyare...
Recent advances in tissue engineering of cartilage, bone, and tendon Purpose of review: The research of tissue engineering includes the study of seed cells, biomaterials, and engineering of different tissue types in animals... W Liu,L Cui,Y Cao - 《Current Opinion in Orthopaedics》 被引量: ...
We compared tissue autofluorescence (see below) for three sample preparation types that have been used previously in the study of tessellated cartilage (Fig.2A): (1) “thawed samples”: non-fixed, non-demineralized and non-embedded; (2) “paraffin samples”: fixed, demineralized and paraffin-em...
TISSUE ENGINEERED COMPOSITES OF DEMINERALIZED BONE MATRIX AND FIBRIN GLUE Demineralized Bone Matrix (DBM) is currently used in various types of orthopaedic applications because of osteoconductive and osteoinductive properties. Fibrin glue is also used in cardiovascular and thoracic surgery due to its hemos...
Coherent anti-Stokes Raman scattering (CARS) and second harmonic generation (SHG) are non-linear techniques that allow label-free, non-destructive and non-invasive imaging for cellular and tissue analysis. Although live-imaging studies have been performe
Tendon–bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartoge
Hypertrophic chondrocytes, driven by the transcription factor RUNX2 (Runt-related transcription factor 2), stop producing and start degrading the structural matrix macromolecules aggrecan and type II collagen, compromising the mechanical integrity of the overall tissue. Therefore, biological interventions ...