The goal of the use of biomaterial scaffolds in cartilage tissue engineering is to provide the cells with a comfortable niche which stimulates cells to synthesize cartilage matrix, and to (temporarily) replace the function of the native matrix until new cartilage has formed. To fulfill that functio...
Proposed substance can be used in medicine as an agent normalizing functions of cartilage tissue.;EFFECT: improved preparing method, valuable medicinal properties of agent.;3 cl, 1 tbl, 1 dwg, 4 exKHAVINSON VLADIMIR KHATSKELEVICHMALININ VLADIMIR VIKTOROVICH...
Articular cartilage is a specialized connective tissue that bears load and reduces friction across moving joints. When damaged, articular cartilage does not heal, but often degenerates further, leading to pain and loss of function. This dissertation focuses on the engineering of anatomically-shaped ost...
This chapter discusses the tissue engineering of cartilage, which has a limited repair capacity. It also recognizes the composition of adult hyaline cartilage with emphasis on cells, type of collagen, and proteoglycans. The cartilage formed in the embryo is gradually changed during development to meet...
Ultimately, the goal of investigators working on cartilage regeneration is to develop a system that promotes the production of cartilage tissue that mimics native tissue properties, accelerates restoration of tissue function, and is clinically translatable. Although this is an ambitious goal, significant ...
2008). These factors and their relationship in tissue function, homeostasis and degeneration have been reviewed by, for example, Gentili and Cancedda (2009), Goldring et al. (2008) and Goldring and Marcu (2009), and are more thoroughly reviewed in the other chapters of this book. The poor...
The elastic (Young’s) modulus of the hESC-derived cartilage tissue constructs (0.91 ± 0.08 MPa) was comparable to full-thickness human articular cartilage (0.87 ± 0.09 MPa). Moreover, we have successfully scaled up the size of the scaffold-free, 3D hESC-derived cartilage ...
The basic science of articular cartilage: structure, composition, and function. 来自 deepdyve.com 喜欢 0 阅读量: 484 作者:AJS Fox,B Asheesh,SA Rodeo 摘要: Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface. Its compressive ...
To address the need for cell-based therapies, functional tissue engineering aims to restore cartilage function by culturing grafts in vitro that recapitulate the mechanical, biochemical, and structural framework of the tissue in order to have an increased chance of integration and survival upon in ...
Hyperspectral microscopy is a novel technology which utilises endogenous fluorophores to non-invasively assess the molecular composition of cells and tissue. In this study, we applied hyperspectral microscopy to healthy bovine articular cartilage and osteoarthritic human articular cartilage to investigate its...