ObjectiveTo evaluate the rate of progression of cartilage loss in the knee joint using magnetic resonance imaging (MRI) and to evaluate potential risk factors for more rapid cartilage loss.SandipStanfordBiswalStanfordTrevorStanfordHastieStanfordThomas...
Prior investigations of magnetic resonance imaging (MRI) biomarkers of cartilage loss in knee osteoarthritis (OA) suggest that trials of interventions which affect this biomarker with adequate statistical power would require large clinical studies of 1–2 years duration. We hypothesized that smaller, sho...
"We found that patients without knee osteoarthritis who underwent meniscal surgery had a highly increased risk for developing osteoarthritis and cartilage loss in the following year compared to those that did not have surgery, regardless of presence or absence of a meniscal tear in the year before,...
The repair of articular cartilage needs a sufficient number of chondrocytes to replace the defect tissue, and therefore, expansion of cells is generally required. Chondrocytes derived by cellular reprogramming may provide a solution to the limitations of current (stem) cell-based therapies. In this ...
Terms including de-, re-, and trans-differentiation represent alterations in the synthetic profile of adult somatic cells that may be relevant to tissue regeneration9. Dedifferentiation, a loss of cellular functionality, is a term with no definitive mechanism, yet is used to describe distinct and ...
Transection of the anterior cruciate ligament in the knee leads to a reproducible defined () with erosive cartilage loss, subchrondral sclerosis, and osteophyte formation, enabling studies of cartilage biochemistry before morphological changes are apparent. As early as 1 week after operation, menisci ...
MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3 years. Cartilage was graded 0-4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss, and in secondary analyses with compartment-specific ...
Conaghan PG, Felson D, Gold G et al (2006) MRI and non-cartilaginous structures in knee osteoarthritis. Osteoarthr Cartil 14(Suppl A):A87–A94 PubMed Google Scholar Cicuttini FM, Jones G, Forbes A et al (2004) Rate of cartilage loss at two years predicts subsequent total knee arthrop...
(age 60.6 ± 9.6 y; BMI 27.8 ± 4.8) with definite osteophytes in one knee (earlyROA, n = 32) and with ROA risk factors in the contralateral knee (riskROA, n = 28), and 89 healthy subjects (age 55.0 ± 7.5 y; BMI 24.4 ± 3.1) without ...
With the Soft Delivery System (SDS) from Sulzer Medica, cartilage defects in joints (thus so far in the knee, ankle joint and hip) can be treated. Autologous cartilage-bone plugs are transplanted, in which the cartilage during removal and transfer is treated very gently, thanks to the specia...