The human spine serves multiple structural and physiologic roles. An essential function of the spinal column in all vertebrates is to integrate the brain and nervous system with the axial skeleton and simultaneously protect the spinal cord. For humans, the symmetry and position of the spine is key...
As depicted in Fig.1, the device is composed of a handheld arthroscopic extruder and a supply unit. The handheld extruder includes a bendable tip whose hollow structure is made of nitinol, a biocompatible material featuring asuperelasticresponse. The tip can be bent up to 90° around the x-a...
Here, we examined the expression and localization of HYBID in human articular cartilage tissues, and found that HYBID is up-regulated by chondrocytes in HA-depleted areas of the OA cartilage and that immunolocalization of HYBID directly correlates with Mankin score. We also provide evidence that ...
distinct stage of lizard tail regeneration - Stage 2 as described here, corresponding to approximately 4–6 weeks post autotomy. This finding may be controversial because conventional theories dictate that the lizard tail is completely boneless, i.e., that no portion of the cartilage tube ossifie...
Cartoon depiction of a cartilage cell and surrounding matrix. Fibrillar collagens are shown in pink, while sulfated proteoglycan (e.g. aggrecan, perlecan) is shown as a complex with link protein and hyaluronic acid. The adhesion G protein receptor GPR126 is depicted interacting with a laminin ...
(or a potential drug carrier such as avidin) is injected intra-articularly47,52, there is an immediate sharp increase in its concentration just inside the cartilage due toDonnan partitioningat the synovial fluid–cartilage interface50(Fig. 3a). As depicted inFig. 3a, the resulting increased ...
To investigate whether AS is involved in OA pathogenesis, we depicted the AS landscape in cartilage tissues from patients with OA and donors without OA using the RNA sequencing (RNA-seq) datasets (GSE114007)11(Fig.1a-I). We identified a total of 624 differential AS events (DASEs) in the...
Here we actually confirm that a reduced response is indeed the case. Previously, the effects of TGFβ on chondrocytes of different ages have been studied using chondrocytes cultured in monolayer, but this has yielded variable results on a common parameter as proteoglycan production14, 44, 45. ...
The grid quality diagram is shown in Figure 3c, which proves that the grid quality in this simulation is better. The process of needle extrusion’s pressure gradient is depicted in Figure 3d. Apply 2 bars of pressure on the needle barrel and set the inlet and outlet of pressure from the ...
The entire classification procedure for the recognition of cartilage loss is depicted in Figure 13. Figure 13. Flowchart of the whole classification design for early cartilage loss classification based on the segmentation data from genetic algorithm-based clustering. Table 8. Hyperparameter settings ...