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Mechanical injury is considered to be a major inductor of articular cartilage destruction and therefore a risk factor for the development of secondary osteoarthritis. Mechanical injury induces damage to the tissue matrix directly or mediated by chondrocytes via expression of matrix-degrading enzymes and ...
Rheumatoid arthritis (RA) is a chronic disabling disease characterised by synovitis, destruction of cartilage and bone and, ultimately, loss of joint function. A great deal of research in rheumatology over the past two decades has focused on identifying cytokines and other mediators responsible for ...
of T-cell immunity Activating FcγRIII determines cartilage destruction during immune complex arthritis but not in the presence of T-cell immunityActivating FcγRIII determines cartilage destruction during immune complex arthritis but not in the presence of T-cell immunitydoi:10.1186/ar484...
Joint Pain, Severe Cartilage Destruction, and Chondrolysis: Guidelines for Improving Diagnostic Differentiation and Clinical Management (SS-22)Joint pain and concomitant function loss are among the most common complaints encountered by orthopedic surgeons. One emerging condition in which an entire joint ...
Stimulation of chondrocytes derived from healthy and OA tissues with IL-1β, a cytokine known to mediate cartilage destruction, suppressed miR-125b expression and was associated with concomitant upregulation of ADAMTS-4 mRNA expression. Furthermore, transfection of chondrocytes with precursor miR-125b...
IELTS 英[ˈkɑ:tɪlɪdʒ] 美[ˈkɑrtɪlɪdʒ] 释义 n. <解>软骨;软骨结构 词态变化 复数:cartilages; 实用场景例句 全部 软骨 ...a serious kneecartilageinjury. 膝部软骨组织严重受伤 柯林斯高阶英语词典 MMP 1 is an enzyme that degrades collagen, a protein found in bone and...
Cartilage destruction in experimentally induced osteoarthritis. Vignon E, Hartmann JD, Vignon G, Moyen B, Arlot M, Ville G. Cartilage destruction in experimentally induced osteoarthritis. J Rheumatol 1984;11:202-7.Vignon E, H a r t m a n n DJ, Vignon G, Moyen B, Arlot M, Ville G......
If microgravity is detrimental to cartilage, would gravity at the surface of the moon (0.16 G), or Mars (0.38 G), be sufficient to maintain tissue regeneration pathways and prevent uncontrolled cartilage destruction? Efforts are underway to explore the use of fractional gravity generated by...
Methods To study the time course and mechanisms of inflammatory destruction of articular cartilage, we used the human TNFα transgenic (hTNFtg) mouse model of rheumatoid arthritis. hTNFtg mice were sacrificed from weeks 2 to 14 in 2-week intervals, and sections of the hind paws were analyzed...