[2]Chen T,et al.Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors[J]. Cancer Cell International, 2024, 24(1): 133.https://cancerci.biomedcentral.com/articles/10.1186/s12935-024-03315-3 [3]Shi Y,et al.Combined local therapy and CAR㏄C3 T〆ll therapy...
Chimeric antigen receptor (CAR) T cells therapy has emerged as a significant breakthrough in adoptive immunotherapy for hematological malignancies with FDA approval. However, the application of CAR-T cell therapy in solid tumors remains challenging, mostly due to lack of sui...
[1]Daei Sorkhabi A,et al.The current landscape of CAR T-cell therapy for solid tumors: Mechanisms, research progress, challenges,and counterstrategies. Front Immunol.2023 Mar 20;14:1113882.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067596/ [2]Li H,et al.CAR-T cells for Colorectal ...
而且,临床前模型中的组合治疗策略已经成功,表明了转化为临床应用的潜力,并且将来需要更多的临床研究来评估组合疗法的效果。 ~Am J Cancer Res 2020;10(7):1979-1992,<Innovative strategies to advance CAR T cell therapy for solid tumors>
[1]Daei Sorkhabi A,et al.The current landscape of CAR T-cell therapy for solid tumors: Mechanisms, research progress, challenges,and counterstrategies. Front Immunol.2023 Mar 20;14:1113882. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067596/ ...
参考文献:https://www.archivesofmedicalscience.com/Mesothelin-targeted-CAR-T-cells-for-adoptive-cell-therapy-of-solid-tumors,106265,0,2.html 以下是CAR-T治疗实体瘤中非常有潜力的靶点。 05、CEA CEA叫做癌胚抗原,是临床上常用的肿瘤标记物。有研究表明,靶向CEA的CAR-T疗法有助于延长晚期胃癌小鼠的生存时...
新闻来源：New CAR T-cell Therapy for Solid Tumors Was Safe and Showed Early Efficacy 根据2022年4...
我国科学家最近在《Journal of Hematology and Oncology》杂志发表“IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin”。该论文报道了两例采用CAR-T技术在实体肿瘤中的治疗应用。 一例晚期肝癌患者接受了瘤内注射第四代CAR-T治疗后,肝脏病灶代谢基本消失;另一例晚...
参考资料: https://www.aacr.org/about-the-aacr/newsroom/news-releases/new-car-t-cell-therapy-for-solid-tumors-was-safe-and-showed-early-efficacy/
But the curative effect of CARTtherapy for solid tumors in recent years has been no substantive breakthrough. There are many problems to be solved in tumorimmunotherapy of solid tumor. For example,how CART break through into solid tumor microenvironment and keep vitality,how toidentify cancer ...