carnitine‐orotatefatty liverinsulin resistancemetforminoxidative stressBackground and AimEffective medicines have not been introduced for insulin resistance-related fatty liver. The efficacy and safety of treatment between a combination of metformin and carnitine-orotate complex and metformin...
SolubilityDMSO (Slightly, Heated), Water (Slightly) AppearanceSolid ColorWhite to Off-White Storage ConditionHygroscopic, -20°C Freezer, Under inert atmosphere StabilityHygroscopic L-Carnitine orotate -Reference Information Pharmacological effectsL-carnitine orotin is an ionic complex salt formed by pharma...
particularly acid maleate: orotate; oxalate, particularly acid oxalate: sulphate, particularly acid sulphate: trichloroacetate; trifluoroacetate and methansulphonate. ##STR3## EXAMPLE 1 Preparation of Isovaleryl-L-Carnitine Undecyl Ester Chloride (ST 722) Step A: Preparation of Isovaleryl-L-...
OROTATE COMPLEXQUALITYBackground and objectiveThe efficacy and safety of L-carnitine supplementation on non-alcoholic fatty liver disease (NAFLD) are unclear. This systematic review and meta-analysis aimed to assess the efficacy and safety of L-carnitine supplementation on NAFLD.MethodsWe searched in ...
The inclusion criteria were as follows: (a) patients: diagnosis of chronic liver disease; (b) intervention: taking the target drugs, including carnitine-orotate, carnitine-orotate complex, andl-carnitine; (c) comparator: no target drugs; (d) outcome: proportion of patients with alanine aminotrans...