then reconverts the acylcarnitine into an acyl-CoA, which is the substrate for mitochondrial long-chainFAO(Fig. 1). Theacyltransferasereaction is reversible, and therefore thenet fluxthrough theenzymewill depend on the concentration of substrates and products. The role of the carnitine cycle i...
In rat liver mitochondria, ME(O)HP inhibited carnitine acyltransferase I (CAT I; EC 2.3.1.21) competitively with the substrates palmitoyl-CoA and octanoyl-CoA. An analogous treatment of mouse mitochondria produced a similar competitive inhibition of palmitoyl-CoA transport whereas ME(O)HP exposure ...
et al. Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of Myc-induced lymphomagenesis. J. Natl. Cancer Inst. 105, 489–498 (2013). Article CAS PubMed Google Scholar Li, J. et al. Inhibition of lipolysis by mercaptoacetate and etomoxir specifically sensitize drug...
are mediated by a group of carnitine acyltransferase enzymes that catalyze the following general reaction: acyl-CoA + L-carnitine −−−−−−−−−−−→ ←−−−−−−−−−−− carnitine acyltransferases ...
Synonyms: Stearoyl-L-carnitine-d3 (chloride);(R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(stearoyloxy)propan-1-aminium,monochloride;O-Octadecanoyl-L-carnitine-d3 Hydrochloride;Stearyl-L-Carnitine-D3 hydrochloride;O-Octadecanoy-L-Carnitine-D3 Hydrochloride CAS: 2245711-27-5 MF: C25H45ClD...
Sirui ZhouLan XiongPingxing XieAmirthagowri AmbalavananCynthia V. BourassaAlexandre DionneLaporteDan SpiegelmanMaude Turcotte GauthierEdouard HenrionOusmane Diallo
(Asaoka 1991; Groot 1975; Lauet al.1977; Osmundsen and Sherratt 1985). Hence a xenobiotic-CoA, which is both resistant to hydrolysis and is not a substrate for theN-acyltransferase, has the potential to sequester intramitochondrial CoASH and perturb β-oxidation. Indeed,carboxylic acidsthat ...
D'Apolito, O. Petillo, L. Rocchi, G. Pasquinelli, R. Nicolai, A. Koverech, M. Calvani, G. Peluso, L. Montanaro Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of myc-induced lymphomagenesis J. Natl. Cancer Inst., 105 (2013), pp. 489-498, 10.1093/...
For example, peroxisomal β-oxidation of di- and trihydroxycholestanoic acid leads to the formation of choloyl-CoA and chenodeoxycholoyl-CoA, then converted by the action of bile acil-CoA: amino acid N-acyltransferase into the taurine and glycine conjugates, which are exported out of the ...
membrane proteinsand they lose catalytic function when solubilized. However, homology analysis of their sequences compared to those of the globular, soluble members of the carnitineacyltransferasefamily (CrAT,COT, CPT2) for which crystal structures have been obtained at a high resolution as well as...