Kleber, H. P. (1997) Bacterial carnitine metabolism, FEMS Microbiol. Lett. 147, 1-9.Kleber HP: Bacterial carnitine metabolism. FEMS Microbiol Lett 1997, 147(1):1-9.Kleber, H.P. (1997) Bacterial carnitine metabolism. FEMS Microbiol Lett 147: 1-9....
We show that, by downregulating the metabolism of lipids through the key molecule carnitine palmitoyl transferase 1 (CPT1), it is possible to reverse or slowdown disease progression in experimental models of autoimmune encephalomyelitis-, SOD1G93A and rotenone models, mimicking these CNS diseases in...
Discovered in meat extracts, carnitine takes its name from the latincarnismeaning meat or flesh. The role of carnitine in metabolism was originally described in insects where it was found to be an essential nutrient for certain species. In many species, including mammals, carnitine is crucial in...
CARNITINE METABOLISM 43 Figure 2 Trimethylamine formation in bacteria by aerobic cleavage of the C 4 -Nbond of carnitine. Retention of 3 H label at carbon 3 ruled out the possibility of a 3-oxo intermediate in this pathway (15). Formation of Trimethylamine ...
Metabolism 48: ... J Pill,HF Kühnle - 《Metabolism-clinical & Experimental》 被引量: 58发表: 1999年 Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice energy expenditure and basal metabolic rate by inhibiting the lipogenesis pathway ...
The transfer of acyl compounds from CoA-esters to carnitine also serves to regenerate cellular-free CoA that is essential for intermediary metabolism. Synthesis of acylcarnitines is catalyzed by a family of carnitine O-acyltransferase enzymes (EC 2.3.1.21, EC 2.3.1.137, and EC 2.3.1.7) that ...
Molecular characterization of thecaioperon necessary for carnitine metabolism inEscherichia coii SummaryThe sequence encompassing thecaigenes ofEscherichia coli, which encode the carnitine pathway, has been determined. Apart from the already identified... K Eichler,F Bourgis,A Buchet,... - 《Molecular...
cai operon necessary for carnitine metabolism in Escherichia coii]]>doi:10.1111/j.1365-2958.1994.tb00470.xSummaryThe sequence encompassing the cai genes of Escherichia coli, which encode the carnitine pathway, has been determined. Apart from the already identified caiB gene coding for the carnitine ...
Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions. This dynamic character of the cellular metabolic network appears enh
L-carnitine is also essential for development of hepatic ketone synthesis, a central pathway for neonatal energy metabolism. Ketone bodies inhibit the oxidation of both glucose and lactate, sparing these metabolic substrates for biosynthetic functions. 展开 ...