Short chain acylcarnitines have attracted a lot of attention in the context of diabetes and insulin resistance, with acetylcarnitine playing again a central role as a master regulator of energy metabolism strategies. Malonylcarnitine (C4-OH) has also been suggested as a metabolite of interest in t...
C12-OH (3-hydroxy dodecanoyl) LCHAD deficiency C14:1 (tetradecenoyl) CACT, CPT II, VLCAD, LCHAD deficiency C14 (myristoyl) CACT, CPT II, VLCAD, LCHAD deficiency C16 (palmitoyl) CACT, CPT I, CPT II, VLCAD, LCHAD deficiency C16-OH (3-hydroxy hexadecanoyl) LCHAD deficiency C18:2 (linoleyl...
L-Carnitine HCl 6645-46-1 Acetyl-L-Carnitine HCL 5080-50-2 Molecular Formula L-Carnitine Base C7H15NO3 L-Carnitine L-Tartrate C18H36N2O12 L-Carnitine Fumarate C7H15NO3.C4H4O4 L-Carnitine HCl (CH3)3N+CH2CH(OH)CH2CO2H · Cl-
Results: Screening of AC profile revealed increased FC, 3-hydroxypalmitoylcarnitine (C16-OH), and 3-Hydroxy octadecanoylcarnitine (C18:2-OH) carnitine levels, while decreased acetyl-carnitine (C2), propionyl-carnitine (C3), butyryl-carnitine (C4), tiglyl-carnitine (C5:1), hexanoyl-carnitine (...
Column: Bonchrom-C18(5 μm) 250 × 4.6 mm Temperature: 30° C. Mobile phase (v/v): 0.05 MKH2PO4/acetonitrile(60/40)(v/v) pH: 3.0 with H3PO4 Detection wavelength(λ): 205 nm Flow rate: 0.6 ml/min Carnitine: Rt = 5.6 min Fumaric acid: Rt = 12.3 min This present inv...
In the ASD group, a significant decrease in C0, C2, C4-OH, C5, C5-OH, C6, C16, C18 carnitines compared to the control group (respectively, p value 0.037, 0.010, 0.005, 0.032, 0.005, 0.003, 0.043, 0.003), and a significant increase in C18: 1 carnitine (p<0.025) was observed in...
Almost all of C2- to C12-carnitine esters were significantly lower, whereas C16- and C18-carnitines with in-chain modifications were significantly higher in mothers at delivery compared with nonpregnant women. Plasma levels of free carnitine and C2-, C3-, C4-, C5-, C6-, and C16-carnitines...
Moreover, the concentrations of the acyl-carnitines – acetyl-L-carnitine (C2), proprionylcarnitine (C3), 3-hydroxy- isovalerylcarnitine (C5OH), miristoylcarnitine (C4), palmitoylcarnitine (C16) and stearoylcarnitine (C18) – were also significantly low in the cases vs controls. Furthermore...
and (iii) the possible presence of a hydroxyl group. For instance, carnitine is C0 (no acyl group), acetylcarnitine is C2 (2 carbons), decadienoylcarnitine is C10:2 (10 carbons, 2 double bonds), hydroxyoctadecenoylcarnitine is C18:1-OH (18 carbons, 1 double bond, 1 hydroxyl group)....
closely resembling the compound of interest.Newborn screeningfor AA, FAOD, and OAD involves analysis of amino acids (for AA) andacylcarnitines(for FAOD and OAD). Metabolites which accumulate in FAO and OAD are detected ascarnitineconjugates of C2-C18 acyl-CoA derivatives which are substrates for...