Knowledge graph as a graph-based data structure can well represent the relationship of medical data in reality, which can much effectively organize and utilize the medical data. Applying the knowledge graph to the medical field can extract effective knowledge from medical information and fuse it to...
In the current study, higher BNP levels in individuals without a known cardiovascular disease were linked to a higher risk of a first myocardial infarction within 6 months in several models. Cardiomyocytes produce BNP in response to strain8, and NT-proBNP measurement is a pillar of the clinical...
8.3.6 Valvular heart disease It develops when the valves of the heart become impaired or defective. Valvular heart diseases are of two types: Stenosis and Regurgitation. Stenosis: Stenosis refers to the inability of the heart valve to completely open during diastole, which obstructs the blood flo...
Apolipoprotein A1 (ApoA1) is a main protein moiety in high-density lipoprotein (HDL) particles. Generally, ApoA1 and HDL are considered as atheroprotective. In prooxidant and inflammatory microenvironment in the vicinity to the atherosclerotic lesion, Ap
A well-integrated dataset is very powerful for a lot of common downstream analysis tasks. Cell typing is much improved when information about both transcriptome and proteome is available, as cells like NK-cells, which play a major role in inflammatory heart disease [142,143], are notoriously ha...
Note. 24 h UNaE: 24 h urinary sodium excretion; CV: cardiovascular; CHD: coronary heart disease; CVD: cardiovascular disease; CHF: congestive heart failure; ONTARGET: Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial; TRANSCEND: Telmisartan Randomized Assessment Study ...
Cardiovascular disease (CVD) prevention guidelines encourage assessment of absolute CVD risk - the probability of a CVD event within a fixed time period, based on the most predictive risk factors. However, few General Practitioners (GPs) use absolute CVD risk consistently, and communication difficultie...
There is also a strong relationship between Obstructive Sleep Apnea Syndrome (OSAS) and cardiovascular disease. This study was designed to investigate the association betweenserum GGT levels and cardiovascular disease in patients with OSAS, and relationship between severity of OSAS and serum GGT level....
Laboratory Investigation (2016) 96, 708–718 © 2016 USCAP, Inc All rights reserved 0023-6837/16 $32.00 PATHOBIOLOGY IN FOCUS ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease Dimitry A Chistiakov1, Alexander N Orekhov2,3 and Yuri V Bobryshev2,4,5 Apolipoprotein A1 (ApoA1...
signaling is critical for cardiac function; therefore, identifying the network of cardiac proteins that rely on ALPK3 activity may provide insights into the intracellular signaling mechanisms used to control cardiac contractility and, in turn, HCM disease progression, while suggesting new therapeutic ...