The Tei index is associated with mortality in patients with DCM, with those having a high Tei index (>/=0.76) experiencing shorter life expectancy [20]. Additionally, a high echocardiography-derived hemodynamic forces angle is associated with major adverse cardiovascular events (MACE) in DCM ...
whereas sudden cardiac death from arrhythmias accounts for the remaining 30%15,16,17,18,19,20. Survival of patients with DCM who develop heart failure has improved over time in developed countries. Improvements in survival have been attributed in large part to the increased availability...
Clinical presentation of HCM varies from completely asymptomatic with normal life expectancy, to typical symptoms like chest pain, shortness of breath, heart failure, palpitations, syncope, and in the worst case even sudden cardiac death [2, 6]. Complications of non-obstructive HCM include advanced...
Recently, we showed that a medium-chain triglyceride containing ketogenic diet (MCTKD) improves skeletal muscle function and pathology in a CRISPR/Cas9 gene-edited rat model with DMD. In this study, we sought to clarify whether MCTKD also improves the cardiomyopathy in these rats. DMD rats ...
Hypertrophic cardiomyopathy (HCM) is now recognized as a relatively common contemporary and treatable disease, not inevitably progressive, with potential for low mortality, and compatible with normal or extended life expectancy. Introduction HCM is a relatively common inherited heart disease with diverse ...
1Department of Cardiology, Angiology and Pneumology, University Hospital, Heidelberg, Germany; 2Institute of Human Genetics, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK; 3Max-Planck Institute for Medical Research, Heidelberg, Germany; 4Division of Epigenomics and Cancer...
The average life expectancy in symptomatic patients is less than 3 years (Lazarevic et al., 2000). However, long-term prognosis in patients with AC (81%) is superior to their counterparts with idiopathic DCM (30%), with transplant-free survival reported to be 20 and 81%, respectivel...
This enhanced ability to diagnose HCM early is being paired with innovations in treatment, which means that the majority of patients receiving a contemporary diagnosis of HCM can anticipate a normal life expectancy and expect to maintain a good functional status and quality of life. Indeed, with ...
https://ror.org/024zgsn52grid.477183.e0000 0004 0399 6982Essex Cardiothoracic Centre Nethermayne Essex SS16 5NL Basildon UKAmy Hardy-Wallacehttps://ror.org/024zgsn52grid.477183.e0000 0004 0399 6982Essex Cardiothoracic Centre Nethermayne Essex SS16 5NL Basildon UKAnthony D. Dimarco...
Its clinical manifestations range from few symptoms and normal life expectancy to severe symptoms and sudden death. Of prognostic interest, mutations in genes associated with FHC can potentially predict the clinical course of disease. For example, the Arg403-Gln mutation at position 403 of the β ...