is a major clinical outcome of diastolic heart failure. A highly local Ca2+influx across the plasma membrane has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the heart specifically decodes the local Ca2+influx as a cytoskeletal reorganizing signal ...
All mice were housed in pathogen-free facilities under a 12-h light/dark cycle with unrestricted access to food and water. Animals were treated in accordance with the approved protocol of the University of North Carolina (Chapel Hill, NC) Institutional Animal Care and Use Committee, which is ...
Both the control and disease-specific (also obtained by applying gene editing techniques) hiPSCs and hiPSC-derived cardiomyocytes are widely available, as they can be obtained from numerous companies or biobank core facilities, such as WiCell Research Institute, Coriell Institute for Medical Research ...
Confocal images were acquired at Spectrography and Bioimaging Facility, and LC-MS analysis was supported by Functional Genomics Facility, NIBB Core Research Facilities. This research was funded by grants from the Japan Science and Technology Agency, Precursory Research for Embryonic Science and ...
Confocal images were acquired at Spectrography and Bioimaging Facility, and LC-MS analysis was supported by Functional Genomics Facility, NIBB Core Research Facilities. This research was funded by grants from the Japan Science and Technology Agency, Precursory Research for Embryonic Science and ...
Stress-induced changes in CARF expression determine cell fate to death, survival, or malignant transformation. Cell Stress Chaperones 2020, 25, 481–494. [Google Scholar] [CrossRef] Wadhwa, R.; Kalra, R.S.; Kaul, S.C. CARF is a multi-module regulator of cell proliferation and a ...
Some reports mention a prevalence of up to 6.6% of cases presented to referral facilities [3]. For the disease to develop, a few predisposing factors’ presence is required. The most important factors are represented by the damage of cardiac valve, most frequently aortic or mitral, alongside ...
Some reports mention a prevalence of up to 6.6% of cases presented to referral facilities [3]. For the disease to develop, a few predisposing factors’ presence is required. The most important factors are represented by the damage of cardiac valve, most frequently aortic or mitral, alongside ...