DNA methylation has been extensively discussed concerning genetic regulation, aging, and cardiac diseases [175]. DNA methyltransferases facilitate DNA methylation at the cytosine ring in CpG islands. The methylation sites near gene transcription initiation sites typically block the initiation of gene transcr...
45 The finding provides a new source of cells for disease modeling, drug screening, and rational and personalized cardiac cell therapy. Due to the off-target effect and unstable editing efficiency of gene editing, more work needs to be done in establishing effective and achievable delivery methods...
Consequently, compared to no cardiac 123I-mIBG screening costs per patient were reduced by USD5500 and USD13,431 over 2 and 10 years, respectively. Screening with cardiac 123I-mIBG imaging resulted in losses of 0.001 and 0.040 life years over 2 and 10 years, respectively. Although larger ...
In the neonatal screening programs for cystic fibrosis, trypsinogen is measured in dried blood spots. In cystic fibrosis, pancreatic ducts are blocked, due to a membrane chloride ion channel defect, leading to the appearance of the trypsinogen in the blood (Chapter 11). Liver The liver is the...
127 A systematic delirium screening tool such as the Confusion Assessment Method for the Intensive Care Unit or the Intensive Care Unit Delirium Screening Checklist should be used.128,129 The perioperative team should consider routine delirium monitoring at least once per nursing shift.121 Owing to ...
Linkage analysis, candidate-gene screening within families, and genome-wide association studies have linked rare and common genetic variants in the genes encoding TFs with genetically-determined cardiac arrhythmias. Besides its critical role in cardiac development, recent data demonstrated that they control...
Here, using the forward genetic screening in zebrafish, we identified a novel mutation at a highly-conserved leucine residue in ncx1 gene (mutantLDD353/ncx1hL154P) that led to smaller hearts with reduced heart rate and weak contraction. Mechanistically, the number of ventricular but not atrial...
Patients were randomized 1:1 to the screening or no screening groups using a permuted-block randomization scheme.Patient Management Patients randomized to the screening group underwent CCTA screening as detailed in Figure 1. Imaging was performed on a single 64-slice coronary computed tomography (CT)...
The main advantage of cellular models is that they facilitate high-throughput screening of chemical compounds libraries or their various combinations with relatively lower costs and limited number of animals used for experiments. Notwithstanding, such models should be continuously improved and adapted to ...
E. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J. Mol. Cell. Cardiol. 72C, 126–137 (2014). 23. Gaborit, N. et al. Gender-related differences in ion-channel and transporter subunit expression in...