Postnatal development of the VCS The VCS shares its developmental origins with working cardiomyocytes but becomes specialized during embryogenesis at around embryonic day (E)16.5 in the mouse through downregulation of the sarcomeric contractile apparatus and expression of specific ion channels and connexin ...
The diagnosis is usually made using imaging strategies such as computed tomography or ventilation-perfusion (VQ) scan. The role of cardiac markers for the diagnosis of pulmonary embolism is limited. Troponins are neither a sensitive or specific marker for pulmonary embolism. For example, one study...
Referral to mental health specialists can be useful for more sophisticated clinical evaluations and administration of detailed, diagnostic symptom inventories (e.g., SCID (First et al., 2015), SCAN (Wing et al., 1990)) that can help mitigate the issues of symptom overlap between anxiety and ...
DNA methylation has been extensively discussed concerning genetic regulation, aging, and cardiac diseases [175]. DNA methyltransferases facilitate DNA methylation at the cytosine ring in CpG islands. The methylation sites near gene transcription initiation sites typically block the initiation of gene transcr...
Magnetic resonance (MR) images were obtained with a BRUKER PharmaScan 7 T, 300 MHz scanner using a RARE 8 pulse sequence with the following parameters: TE 39.8 ms, TR 2571 ms, FOV 35 × 35 mm, Matrix 256 × 256, Slice 1 mm (total of 7 slices), 3 averages, total scan time 4 mi...
The glucose analogue [18F]FDG was provided as a bulk vial (Gluscan, GE Healthcare), from which a sample of 18.5 MBq in 0.1 ml was injected. To avoid the intake of carbohydrates, the mice that received [18F]FDG were provided a fat-enriched diet. ...
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prior history of heart disease. To address this i
3D-Body-scan als anthropometrisches Verfahren Zur Bestimmung Der Spezifischen Körperoberfläche. Ernährungs Umschau. 2010;57:178–83. Google Scholar Boston Children’s Hospital z-score Calculator. Obtainable from http://zscore.chboston.org/ (Last access July 2020). Neilan TG, Pradhan...
Early identification of causes and consequences of cardiac arrest is generally considered of importance, in order to prevent recurrence and subsequent clinical deterioration. Apart from coronary angiography, a brain and chest CT-scan can also be performed at admission, when an extra-cardiac cause is ...
In all cases, there was excellent agreement between the location and pattern of midwall fibrosis from the in vivo CMR scan and regions of replacement fibrosis seen in the explanted hearts (Figure 2). The hearts of 9 patients with no midwall fibrosis on CMR, who either died (n = 7) or...