Modified heart muscle cells (sinoauricular node, atrioventricular node, bundle of His, and Purkinje fibers), discussed in Chapter 11, function as the neural elements of the heart that regulate and coordinate its pumping action. • Ventricular muscle cells are larger than atrial muscle cells. ...
The human heart is a complex, multicellular organ with limited regenerative capacity. In vitro modeling of the human heart is not only important to better understand the composition and function thereof, but also to understand diseases or drug response. Cardiac tissue engineering and three-dimensional...
Histology of cardiac muscle cells in the heart - cardiomyocytes, intercalated discs, and lipofuscin pigment.
Cardiomyocytes account for ~80% of the cellular volume and 30%-40% of the total cell population in the heart. Thus, cardiomyocyte senescence affects normal heart function. Senescent cardiomyocytes are characterized by irregular shortening, elevated pacing frequency, dysregulated contraction, and SASP fac...
A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune cells, and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known as cell-cell interactions (CCIs), which are essent...
A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune cells, and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc. Natl Acad. Sci. USA 90, 347–351 (1993). CAS PubMed Google Scholar Han, X. et al. Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of ...
The basic functional unit of the heart is the cardiac muscle cell or myocyte. Upon receiving a small electrical stimulus, the myocyte undergoes a long lasting change in transmembrane voltage, called an action potential, which allows calcium to enter the cell, which in turn triggers a calcium ...
Success in heart regeneration depends on endocardial innate immune signaling The endocardium is activated immediately after injury and promotes cardiac muscle regeneration by producing growth factors. Research now shows that innate immune signaling is crucial for the regenerative function of the endocardium...
form the conduction system of the heart. Except for Purkinje cells, they are generally much smaller than the contractile cells and have few of the myofibrils or filaments needed for contraction. Their function is similar in many respects to neurons, although they are specialized muscle cells. Myoc...