Fibroblast Growth Medium (Cat# MD-0011) References [1] Sabri A, Short J, Guo J, Steinberg SF. (2002) “Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and ...
Our hypothesis was that aprocitentan could reduce the proliferation rate and mitochondrial ROS production induced by TGF-尾 in human cardiac fibroblasts (HCFs). HCFs were isolated from hearts from fully de-identified cadaveric donors and cultured in cardiac fibroblast growth medium. HCFs were treated...
Murine C4 fibroblasts, a murine fibroblast cell line derived from embryonic BALB/c mice by SV40 infection in vitro36, were cultured in Iscove medium (Sigma Aldrich, Munich, Germany) supplemented with 10% FCS (Biochrom) and 1% penicillin/streptomycin (Biochrom). For stimulation experiments, 60,000...
sustained pathological hypertrophy can develop into heart failure and cause sudden death. Fibroblast growth factor 20 (FGF20) is a member of the fibroblast growth factor family, which involved in apoptosis, aging, inflammation, and autophagy. The ...
Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis Crosstalk between the FGFR pathway and other signaling cascades controls skeletal precursor cell differentiation. Genetic analyses revealed that the interplay of ... H.,Miraoui,P.,... - 《Science Signaling》 被引量: 119发表: 2010...
[134]. Similarly, the fibroblast-cardiomyocyte interaction is mediated by paracrine secretion, including Ang II, cardiotrophin 1, fibroblast growth factor (FGF), IL-6, insulin-like growth factor 1 (IGF1), TGFβ, and TNFα (Fig.1) [135]. Fibroblasts also produce IL-33 to inhibit ...
It is believed that impaired BCAA catabolism in cardiac fibroblast (CF) might may also affect the BCAA metabolism of other cardiac cells, which needs more solid evidence in future studies. Considering that periostin may be an important player in the pathological processes of DCM, the potential ...
We show that SFM supplemented with basic fibroblast growth factor, transforming growth factor-尾 and platelet-derived growth factor, enhanced cCFU-F colony formation and long-term self-renewal, while maintaining cCFU-F potency. cCFU-F cultured in SFM maintained a higher proportion of PDGFR伪 + ...
(rCREG, 2.5 μg/ml or 5 μg/ml, Abcam) was added to the cultured medium for 24 h. CREG siRNA or rCREG was delivered into cells to examine the effect of CREG on cardiac fibroblast activation under hypoxia. To clarify the role of CDC42 on the functions of cardiac fibroblasts,...
Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with stable angina...