Among the 20 scans positive for CS, 8 (40%) had findings of both cardiac and extra-thoracic sarcoid. CONCLUSION: Our study shows that 40% of CS patients also have FDG PET-CT findings of extra-thoracic sarcoid. This makes an intriguing case for FDG PET-CT use with pretest diet prep ...
Abbreviations: PET, positron emission tomography; CMR, cardiac magnetic resonance; LGE, late gadolinium enhancement; FDG, fluorodeoxyglucose. A number of prior studies have investigated whether the presence of LGE imaging on CMR can serve as a reliable indicator of sarcoid infiltration of the heart....
18F-FDG PET/CT has emerged as a promising imaging modality, but is challenged by physiological myocardial glucose uptake. An alternative tracer, 68Ga-DOTANOC, binds to somatostatin receptors on inflammatory cells in sarcoid granulomas. We therefore aimed to conduct a proof-of-concept study using...
PET and FDG provides information on inflammatory disease activity.30 Moreover, demonstration of flow abnormalities with PET perfusion imaging suggests myocardial fibrosis.31 With MRI, early enhancement of sarcoid granulomas on T2-weighted images suggests the presence of inflammation and edema, whereas LG...
Gormsen LC et al. A dual tracer (68)Ga-DOTANOC PET/CT and (18)F-FDG PET/CT pilot study for detection of cardiac sarcoido- sis. EJNMMI Res. 2016;6(1):52.Gormsen LC, Haraldsen A, Kramer S, Dias AH, Kim WY, Borghammer P. A dual tracer 68Ga-DOTANOC PET/CT and 18F- FDG ...
An UpToDate review on “Cardiac sarcoidosis” (McKenna, 2013) states that “In patients with abnormalities after the initial evaluation, we suggest noninvasive imaging, preferably with cardiovascular magnetic resonance imaging (CMR) and FDG PET to enhance disease detection and monitoring of treatment ...
18FDG-PET-CT After a fasting period of 18 h18FDG was applied as radioactive tracer for differentiation between normal and inflammatory myocardial tissue using the PET-CT technique (Geminin TF 64, Philips Healthcare, Eindhoven, Netherlands). The last meal before the fasting period began was low...
Optimizing cardiac sarcoid imaging with FDG PET: Lessons from studies of physiologic regulation of myocardial fuel substrate utilization.doi:10.1007/S12350-018-1438-XRonald G. SchwartzSaurabh MalhotraSpringer International Publishing
Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring: Addition to the Expert Consensus.doi:10.2967/JNUMED.118.221549Yang LuNadera J. SweissSociety of Nuclear Medicine
Sperry BW, Tamarappoo BK, Oldan JD, et al. Prognostic impact of extent, severity, and heterogeneity of abnormalities on 18F-FDG PET scans for suspected cardiac sarcoidosis. JACC Cardiovasc Imaging 2018;11:336-45.Sperry BW, Tamarappoo BK, Oldan JD, et al. Prognostic Impact of Extent, ...