Furthermore, when we performed invasive electrophysiological studies in 12–20 week-old cardiomyocyte-specific CAP2-null and age-matched control mice, we saw a significant increase in the HV-interval and AV Wenckebach cycle length in cardiomyocyte-specific CAP2-null mice versus control mice (Table...
altered phenotypes6. In the mammalian genome, CTCF is dose-dependently required for looping between CTCF target sites and insulation of topologically associating domains (TADs)7. In a mouse model, cardiomyocyte-specific inducible depletion of CTCF caused profound transcriptional dysregulation and heart fai...
In HCM iPSC-CMs compared to control iPSC-CMs, electrophysiological abnormalities, disordered sarcomeres, and a substantial increase in genes important for cell proliferation were seen. They discovered that using verapamil plus the histone deacetylase inhibitor trichostatin A (TSA) abolished irregular ...
Equally, in patients with normal LVEF but significant fibrosis, it could be reasonable to perform an electrophysiological study and to implant an ICD if sustained ventricular arrhythmias are inducible.96,119,120 Antiarrhythmic drugs such as β-blockers, amiodarone, and sotalol might be considered, ...
[147]. However, practical applicability of PSC-CMs is mainly limited by their immature phenotype that is characterized by short and less organized sarcomere, absence of transverse tubules (T-tubules), reduced contractibility, altered metabolic, and electrophysiological properties, as compared adult CMs...
By Diagnostic Tests and Services (Echocardiography [Transthoracic Echocardiography], Stress Testing [Exercise Stress Testing, Pharmacological Stress Testing], Cardiac Catheterization and Angiography [Coronary Angiography, Percutaneous Coronary Intervention], Cardiac Biomarker Testing, Electrophysiological Studies [Elect...
Aetna considers cardiac catheter ablation proceduresFootnote1* with electrophysiological studies medically necessary for any of the following arrhythmias: Atrial fibrillation (AF) In members with AF who meet any of the following: AF when the drugs are contraindicated; or AF when the tachycardia is drug...
ICH guidelines recommending preclinical tests have been established in attempt to eliminate the risk of drug-induced arrhythmias. However, in the clinic, arrhythmia occurrence is determined not only by the inherent property of a drug to block ion currents and disturb electrophysiological activity of ...
Electrophysiological parameters like the sinus node recovery time (maximum return cycle length after 10 s fixed-rate pacing), Wenckebach periodicity (longest cycle length with loss of 1:1 atrioventricular-nodal conduction), atrioventricular-nodal refractory period (longest extrastimulus cycle length with ...
All electrophysiological data were recorded and analysed using pCLAMP 9.2 (Mole- cular Devices, St Gre´goire, France). All chemicals were from SIGMA (St Quentin Fallavier, France). Ca2 þ imaging and analysis of LCRs. Spontaneous [Ca2 þ ]i transients and LCRs were recorded in SAN ...