This chapter reviews the normal path of electrical conduction in the heart. In the structurally normal heart, the cardiac impulse is automatically generated by the pacemaker of the heart, the sinus node, and terminates in the ventricular myocardium. The anatomy and physiology of the electrical ...
An innovative idea could be to develop a system for identifying and characterizing microcurrents potentially not involved in contraction, but relevant (together with other physical and biological signals) in cell–cell communication to determine the cell fate. In this context, we proposed a ...
The intrinsic conduction system of the heart is comprised of several specialized subpopulations of cells that either spontaneously generate electrical acti... Laske, Timothy G.,Iaizzo, Paul A. - Anatomy and Physiology Overview of the Cardiac Conduction System 被引量: 0发表: 2024年 Development of ...
Within the most upregulated response pathways, we also explored signaling responses previously implicated in the modulation of cardiac conduction. The Notch signaling pathway, which plays an important role in conduction system development31,32,33, was present at both timepoints (Fig.5a). Furthermore,...
wall development, and their absence causes coronary vascular malformations. cTMs are located throughout cardiac tissues and are closely related to blood vessels to regulate the supply and discharge of blood. cTMs are also abundant in the cardiac conduction system97,98. In the steady state, cTMs ...
Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction system The function of the ventricular specialized conduction system in the heart is to ensure the coordinated electrical activation of the ventricles. It is ther... R.,Bordas,and,... - 《Progress...
Cx40 knock-in Cx45 mice were generated to explore the ability of Cx45 to replace Cx40, and to assess the functional equivalence of these two Cxs that are both expressed in the conduction system. ECGs revealed that the consequences resulting from the biallelic replacement of Cx40 by Cx45 ...
Table 19.2 summarizes the four important electrical characteristics of the AV node previously discussed. Note that three of these characteristics are influenced by the nervous system. As indicated in the table, sympathetic activity increases the conduction velocity of the AV node cells, shortens their...
The intrinsic conduction system of the heart is comprised of several specialized subpopulations of cells that either spontaneously generate electrical activity (pacemaker cells) or preferentially conduct this activity throughout the chambers in a coordinated fashion. This chapter will discuss the details of...
In addition, we describe a heart preparation with intact innervation by the vagus nerve that can be used as an ex vivo model for vagal control of the cardiac conduction system. Data acquisition for in vivo and ex vivo electrophysiological study takes ~1 h per mouse, depending on the number ...