OCR A Level PE - Cardiovascular System at rest (structure, path of blood, conduction system & cardiac cycle) 22 terms lottie_1850 Preview The mammalian heart. 12 terms jackradford05 Preview YR13 Biology - Unit 5 43 terms sena379 Preview Initiation of Heart Beat 62 terms Laura_Ade...
L. Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction. Transl. Res. 191, 15–28 (2018). Article PubMed Google Scholar Bajpai, G. et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat. ...
Since SKP2 inhibitors might ultimately induce cell-cycle arrest, we studied the causal role of T623 on cell cycle activity and cardiac maturation. We found 1 µM reduced the cell proliferation ratio, but a suboptimal concentration of 40 nM did not (Supplementary Fig. 4g). SKP2 inhibito...
Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-lowering and weight loss medication due to its effects on energy metabolism. In heart failure, energy production is impaired due to altered mitochondrial function an
2.9. The level and mobilization of ferrous iron The levels of cardiac total iron and ferrous iron were measured using the iron assay kit (Abcam, 83366). A microplate reader was used to measure the absorbance at 593 nm. The content of intracellular and mitochondrial ferrous iron in AC16 was...
3A). There was a significant decrease in the basal OCR values of mitochondria from aged-WT mice heart compared to young-WT mice indicating the impaired Complex I activity in the Sesn2 defected heart (Fig. 3C). When rotenone was injected the OCR came to baseline level indicating inhibition ...
Measurements Peak oxygen uptake Participants performed a progressive exercise test to maximal voluntary exertion using an electromagnetically braked cycle ergometer (Lode Excalibur Sport V2.0, Groningen, The Netherlands). Following a 3 min warm-up at a fixed workload of 50 W, a ramp protocol was...
The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of dysfunctional mitochondria, and defects in this process contribute to a variety of cardiometabolic and neurological diseases. Although recent ...
Heart organoids are comparable to age-matched human fetal cardiac tissues at the transcriptomic, structural, and cellular level. They develop sophisticated internal chambers with well-organized multi-lineage cardiac cell types, recapitulate heart field formation and atrioventricular specification, develop a ...
but in some exceptional cases, there was good correlation with a reference method. Many of these studies refer to the poor physical principles of the thoracic impedance method as described in Patterson “Fundamentals of impedance cardiography”, IEEE Engineering in Medicine and Biology 1989; 35 to ...