The propagation of the action potential in contractile artrial and ventricular fibres is explained by this simulated electronic circuit which has a one-to-
Sudden infant death syndrome (SIDS): a study of cardiac conduction system. Cardiovasc Pathol. 2000; 9 :137–45.Matturri L, Ottaviani G, Ramos SG, Rossi L (2000) Sudden in- fant death syndrome (SIDS): a study of cardiac conduction sys- tem. Cardiovasc Pathol 9:137-145...
We revealed their close relationship with sympathetic innervation during cardiac conduction system formation. Our study thus provides new insights into the development and heterogeneity of the mammalian cardiac conduction system by revealing a new cardiomyocyte population with potential catecholaminergic endocrine...
HCN4 is expressed in the sinoatrial node. (A) Right, schematic diagram of the cardiac conduction system (green). The primary pacemaker site is the sinoatrial node (SAN). The atrioventricular node (AVN) is the only electrically conductive connection between the atria and the ventricles. The bund...
The difference in LGE pattern could be explained by the different tropism of viruses. In fact, human herpesvirus 6 infects not only T cells but also cells of the nervous system and the cardiac conduction system, and it can establish a latent state after primary infection (20). After a prim...
These discrepancies could be explained by the different strategies of gene targeting adopted and/or by the presence of the other HCN-channel isoforms that can compensate for the loss-of-function of HCN4 channels in both the SAN and cardiac conduction system. Furthermore, deletion of the HCN4 ...
Within the most upregulated response pathways, we also explored signaling responses previously implicated in the modulation of cardiac conduction. The Notch signaling pathway, which plays an important role in conduction system development31,32,33, was present at both timepoints (Fig.5a). Furthermore...
(conduction system) that allows an electrical impulse to rapidly spread throughout the heart. A cardiac cycle is created when such an impulse propagates through the conduction system. The electrical impulse is the event that triggers the mechanical force, and thus the electrical event precedesheart...
Development of the human cardiac conduction system The human heart becomes the first functional organ at the beginning of the 3rd week of development. After 21 days of embryogenesis, a human embryo measures less than 5 mm, and the primordial heart is a “cardiac tube” that is connected to ...
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are multisystemic diseases clinically characterized by myotonia, progressive skeletal muscle weakness, conduction defects, and central nervous system involvement. Family pedigree and clinical family screening may demonstrate the phenomenon of anticipation, that ...